{"title":"大黄的植物学、传统用途、植物化学、药理学和临床应用:系统综述。","authors":"Haonan Xu, Wei Wang, Xinzhuo Li, Yuze Li, Yi Jiang, Chong Deng, Xiaomei Song, Dongdong Zhang","doi":"10.1142/S0192415X24500757","DOIUrl":null,"url":null,"abstract":"<p><p>Rhubarb, the Rhei radix et rhizoma (Da huang) is a member of the Polygonaceae family, included in the 2020 edition of the Chinese Pharmacopoeia, and is mainly distributed in Gansu, Sichuan, Qinghai, northwestern Yunnan, and eastern Tibet. Rhei radix et rhizoma is one of the most commonly used traditional Chinese medicines, processed into drinkable tablets in different concoctions for clinical use. Phytochemical studies showed that more than 170 compounds were isolated and identified from Rhei radix et rhizoma, including anthraquinones/anthrones (major constituents), stilbenes, chromones, flavonoids, tannins, and other compounds, etc. Rhei radix et rhizoma is an herb with a long history of traditional use and many potential therapeutic benefits. It can play the role of diarrhea, clearing heat in response to different combinations and concoctions. It is mainly used for the treatment of constipation, gastrointestinal function impairment, and other diseases. In addition, Rhei radix et rhizoma has significant antitumor, anti-inflammatory, antibacterial, hepato-renal protective, neuroprotective, hypolipidemic, and immunomodulatory activities. Its active constituents have anti-tumor, anti-inflammatory, anti-inflammatory and hepato-kidney protective properties. Although it is primarily used for gastrointestinal disorders, it may also have wider applications in various inflammatory and liver disorders. Therefore, further studies are needed to explore its full potential and mechanism of action. This paper reviews the research progress of Rhei radix et rhizoma in terms of botany, traditional use, chemistry, pharmacology, and clinical studies. It aims to provide a scientific basis for in-depth research and development of Rhei radix et rhizome resources.</p>","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1925-1967"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Botany, Traditional Use, Phytochemistry, Pharmacology and Clinical Applications of Rhubarb (Rhei Radix et Rhizome): A Systematic Review.\",\"authors\":\"Haonan Xu, Wei Wang, Xinzhuo Li, Yuze Li, Yi Jiang, Chong Deng, Xiaomei Song, Dongdong Zhang\",\"doi\":\"10.1142/S0192415X24500757\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Rhubarb, the Rhei radix et rhizoma (Da huang) is a member of the Polygonaceae family, included in the 2020 edition of the Chinese Pharmacopoeia, and is mainly distributed in Gansu, Sichuan, Qinghai, northwestern Yunnan, and eastern Tibet. 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Its active constituents have anti-tumor, anti-inflammatory, anti-inflammatory and hepato-kidney protective properties. Although it is primarily used for gastrointestinal disorders, it may also have wider applications in various inflammatory and liver disorders. Therefore, further studies are needed to explore its full potential and mechanism of action. This paper reviews the research progress of Rhei radix et rhizoma in terms of botany, traditional use, chemistry, pharmacology, and clinical studies. 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引用次数: 0
摘要
大黄(Rhei radix et rhizoma,Da huang)为蓼科植物,收载于 2020 年版《中国药典》,主要分布于甘肃、四川、青海、云南西北部和西藏东部。大黄是最常用的传统中药之一,经不同炮制方法加工成饮片,供临床使用。植物化学研究表明,从大黄中分离并鉴定出 170 多种化合物,包括蒽醌/蒽酮(主要成分)、二苯乙烯类、色酮类、黄酮类、鞣质和其他化合物等。大黄是一种传统使用历史悠久的草药,具有许多潜在的治疗功效。它能针对不同的组合和配伍发挥泻下、清热的作用。主要用于治疗便秘、胃肠功能损伤等疾病。此外,大黄还具有显著的抗肿瘤、抗炎、抗菌、保肝护肾、神经保护、降血脂和免疫调节活性。其活性成分具有抗肿瘤、抗炎、消炎和保护肝肾的作用。虽然它主要用于治疗胃肠道疾病,但在各种炎症和肝脏疾病中也可能有更广泛的应用。因此,还需要进一步的研究来探索其全部潜力和作用机制。本文从植物学、传统用途、化学、药理学和临床研究等方面回顾了大黄的研究进展。旨在为深入研究和开发大黄根茎资源提供科学依据。
Botany, Traditional Use, Phytochemistry, Pharmacology and Clinical Applications of Rhubarb (Rhei Radix et Rhizome): A Systematic Review.
Rhubarb, the Rhei radix et rhizoma (Da huang) is a member of the Polygonaceae family, included in the 2020 edition of the Chinese Pharmacopoeia, and is mainly distributed in Gansu, Sichuan, Qinghai, northwestern Yunnan, and eastern Tibet. Rhei radix et rhizoma is one of the most commonly used traditional Chinese medicines, processed into drinkable tablets in different concoctions for clinical use. Phytochemical studies showed that more than 170 compounds were isolated and identified from Rhei radix et rhizoma, including anthraquinones/anthrones (major constituents), stilbenes, chromones, flavonoids, tannins, and other compounds, etc. Rhei radix et rhizoma is an herb with a long history of traditional use and many potential therapeutic benefits. It can play the role of diarrhea, clearing heat in response to different combinations and concoctions. It is mainly used for the treatment of constipation, gastrointestinal function impairment, and other diseases. In addition, Rhei radix et rhizoma has significant antitumor, anti-inflammatory, antibacterial, hepato-renal protective, neuroprotective, hypolipidemic, and immunomodulatory activities. Its active constituents have anti-tumor, anti-inflammatory, anti-inflammatory and hepato-kidney protective properties. Although it is primarily used for gastrointestinal disorders, it may also have wider applications in various inflammatory and liver disorders. Therefore, further studies are needed to explore its full potential and mechanism of action. This paper reviews the research progress of Rhei radix et rhizoma in terms of botany, traditional use, chemistry, pharmacology, and clinical studies. It aims to provide a scientific basis for in-depth research and development of Rhei radix et rhizome resources.