Sherif S Abdel Mageed, Hanan Elimam, Ahmed E Elesawy, Ahmed I Abulsoud, Ahmed Amr Raouf, Manar Mohammed El Tabaa, Osama A Mohammed, Mohamed Bakr Zaki, Mai A Abd-Elmawla, Walaa A El-Dakroury, Safwat Abdelhady Mangoura, Mahmoud A Elrebehy, Mohammed S Elballal, Aya A Mohamed, Alaa Ashraf, Mustafa Ahmed Abdel-Reheim, Ali M S Eleragi, Hussein Abdellatif, Ahmed S Doghish
{"title":"揭示 miRNA 对痛风性关节炎的影响：诊断意义和治疗机会。","authors":"Sherif S Abdel Mageed, Hanan Elimam, Ahmed E Elesawy, Ahmed I Abulsoud, Ahmed Amr Raouf, Manar Mohammed El Tabaa, Osama A Mohammed, Mohamed Bakr Zaki, Mai A Abd-Elmawla, Walaa A El-Dakroury, Safwat Abdelhady Mangoura, Mahmoud A Elrebehy, Mohammed S Elballal, Aya A Mohamed, Alaa Ashraf, Mustafa Ahmed Abdel-Reheim, Ali M S Eleragi, Hussein Abdellatif, Ahmed S Doghish","doi":"10.1007/s00210-024-03603-9","DOIUrl":null,"url":null,"abstract":"<p><p>Gouty arthritis is a prevalent inflammatory illness. Gout attacks begin when there is an imbalance in the body's uric acid metabolism, which leads to urate buildup and the development of the ailment. A family of conserved, short non-coding RNAs known as microRNAs (miRNAs) can regulate post-transcriptional protein synthesis by attaching to the 3' untranslated region (UTR) of messenger RNA (mRNA). An increasing amount of research is pointing to miRNAs as potential players in several inflammatory diseases, including gouty arthritis. miRNAs may influence the progression of the disease by regulating immune function and inflammatory responses. This review mainly focused on miRNAs and how they contribute to gouty arthritis. It also looked at how miRNAs could be used as diagnostic, prognostic, and potential therapeutic targets.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":"3433-3450"},"PeriodicalIF":3.1000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities.\",\"authors\":\"Sherif S Abdel Mageed, Hanan Elimam, Ahmed E Elesawy, Ahmed I Abulsoud, Ahmed Amr Raouf, Manar Mohammed El Tabaa, Osama A Mohammed, Mohamed Bakr Zaki, Mai A Abd-Elmawla, Walaa A El-Dakroury, Safwat Abdelhady Mangoura, Mahmoud A Elrebehy, Mohammed S Elballal, Aya A Mohamed, Alaa Ashraf, Mustafa Ahmed Abdel-Reheim, Ali M S Eleragi, Hussein Abdellatif, Ahmed S Doghish\",\"doi\":\"10.1007/s00210-024-03603-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Gouty arthritis is a prevalent inflammatory illness. Gout attacks begin when there is an imbalance in the body's uric acid metabolism, which leads to urate buildup and the development of the ailment. A family of conserved, short non-coding RNAs known as microRNAs (miRNAs) can regulate post-transcriptional protein synthesis by attaching to the 3' untranslated region (UTR) of messenger RNA (mRNA). An increasing amount of research is pointing to miRNAs as potential players in several inflammatory diseases, including gouty arthritis. miRNAs may influence the progression of the disease by regulating immune function and inflammatory responses. This review mainly focused on miRNAs and how they contribute to gouty arthritis. It also looked at how miRNAs could be used as diagnostic, prognostic, and potential therapeutic targets.</p>\",\"PeriodicalId\":18876,\"journal\":{\"name\":\"Naunyn-Schmiedeberg's archives of pharmacology\",\"volume\":\" \",\"pages\":\"3433-3450\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Naunyn-Schmiedeberg's archives of pharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00210-024-03603-9\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Naunyn-Schmiedeberg's archives of pharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00210-024-03603-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities.
Gouty arthritis is a prevalent inflammatory illness. Gout attacks begin when there is an imbalance in the body's uric acid metabolism, which leads to urate buildup and the development of the ailment. A family of conserved, short non-coding RNAs known as microRNAs (miRNAs) can regulate post-transcriptional protein synthesis by attaching to the 3' untranslated region (UTR) of messenger RNA (mRNA). An increasing amount of research is pointing to miRNAs as potential players in several inflammatory diseases, including gouty arthritis. miRNAs may influence the progression of the disease by regulating immune function and inflammatory responses. This review mainly focused on miRNAs and how they contribute to gouty arthritis. It also looked at how miRNAs could be used as diagnostic, prognostic, and potential therapeutic targets.
期刊介绍：
Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.
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