Pirasannah Erriah, Sheau Ling Puan, Normi Mohd Yahaya, Wan Nur Ismah Wan Ahmad Kamil, Syafinaz Amin Nordin, Azira Muhamad, Suriana Sabri
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引用次数: 0
摘要
抗菌药耐药性（AMR）是一个重大的全球健康问题，原因是病原体的持续存在和细菌感染中耐药性的出现。细菌衍生的抗菌肽（BAMPs）已成为应对这些挑战的一种有前途的策略。BAMPs 以其多样性和多面性而闻名，是一种显著的生物活性剂，对各种病原体具有强大的抗菌活性。本综述探讨了 BAMPs 的复杂特性和内在机制，强调了它们在应对 AMR 方面的多种应用。此外，该综述还研究了 BAMPs 的机制，分析了有效利用 BAMPs 所面临的挑战，并探讨了它们的潜在应用和相关部署挑战，从而就如何利用 BAMPs 对抗不同领域的 AMR 提供了全面的见解。
Harnessing bacterial antimicrobial peptides: a comprehensive review on properties, mechanisms, applications, and challenges in combating antimicrobial resistance.
Antimicrobial resistance (AMR) is a significant global health concern, due to the persistence of pathogens and the emergence of resistance in bacterial infections. Bacterial-derived antimicrobial peptides (BAMPs) have emerged as a promising strategy to combat these challenges. Known for their diversity and multifaceted nature, BAMPs are notable bioactive agents which exhibit potent antimicrobial activities against various pathogens. This review explores the intricate properties and underlying mechanisms of BAMPs, emphasizing their diverse applications in addressing AMR. Additionally, the review investigates the mechanisms, analyses the challenges in utilizing BAMPs effectively, and examines their potential applications and associated deployment challenges providing comprehensive insights into how BAMPs can be harnessed to combat AMR across different domains.
期刊介绍：
Journal of & Letters in Applied Microbiology are two of the flagship research journals of the Society for Applied Microbiology (SfAM). For more than 75 years they have been publishing top quality research and reviews in the broad field of applied microbiology. The journals are provided to all SfAM members as well as having a global online readership totalling more than 500,000 downloads per year in more than 200 countries. Submitting authors can expect fast decision and publication times, averaging 33 days to first decision and 34 days from acceptance to online publication. There are no page charges.
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