{"title":"SARC-F 分数可间接反映细胞外水分与体内总水分的比率。","authors":"Akemi Hioka, Naoki Akazawa, Naomi Okawa, Shinji Nagahiro","doi":"10.1016/j.clnesp.2024.11.015","DOIUrl":null,"url":null,"abstract":"<p><strong>Background & aims: </strong>In the Asian Working Group for Sarcopenia 2019 guidelines, SARC-F is used to screen for sarcopenia. SARC-F is measured based on five components: strength, assistance with walking, rising from a chair, climbing stairs, and falling. However, it has been reported that SARC-F has high specificity but low sensitivity for sarcopenia screening. Considering that SARC-F is currently recommended for sarcopenia screening, indicating the utility of SARC-F not only in sarcopenia screening but also in other aspects is pivotal. This cross-sectional study aimed to clarify the relationship between the SARC-F score and the extracellular water-to-total body water ratio (ECW/TBW) in community-dwelling older people.</p><p><strong>Methods: </strong>This study included 167 community-dwelling older people (aged ≥ 65) who were able to walk independently and used the SARC-F as a screening test for sarcopenia diagnosis. ECW/TBW and the skeletal muscle mass index (SMI) were measured using bioelectrical impedance analysis. The associations among the SARC-F score, ECW/TBW, and SMI were assessed using Spearman's correlation coefficient. Multiple linear regression analyses of the SARC-F score were conducted. Age, sex, number of medications, pain, medical history, ECW/TBW, and SMI were considered independent variables in multiple linear regression analysis.</p><p><strong>Results: </strong>The analyses revealed a significant positive correlation between the SARC-F score and ECW/TBW (ρ = 0.473, p < 0.001). SMI was significantly and negatively correlated with the SARC-F score (ρ = -0.233, p = 0.002). In the multiple linear regression analysis, ECW/TBW (β = 0.311, p < 0.001) and prevalence of pain (β = 0.169, p = 0.023) were significantly and independently associated with the SARC-F score (R<sup>2</sup> = 0.260). SMI was not significantly associated with the SARC-F score (β = 0.002, p = 0.986).</p><p><strong>Conclusion: </strong>This study revealed a positive correlation between SARC-F score and ECW/TBW in community-dwelling older people, and this relationship persisted even after adjusting for confounding factors. However, there was no correlation between the SARC-F score and SMI. Our study indicated that the SARC-F score may be considered an indirect indicator of ECW/TBW. The score might also be useful for discriminating high and low ECW/TBW. These findings highlight a new use for SARC-F.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The SARC-F score may indirectly reflect the extracellular water-to-total body water ratio.\",\"authors\":\"Akemi Hioka, Naoki Akazawa, Naomi Okawa, Shinji Nagahiro\",\"doi\":\"10.1016/j.clnesp.2024.11.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background & aims: </strong>In the Asian Working Group for Sarcopenia 2019 guidelines, SARC-F is used to screen for sarcopenia. SARC-F is measured based on five components: strength, assistance with walking, rising from a chair, climbing stairs, and falling. However, it has been reported that SARC-F has high specificity but low sensitivity for sarcopenia screening. Considering that SARC-F is currently recommended for sarcopenia screening, indicating the utility of SARC-F not only in sarcopenia screening but also in other aspects is pivotal. This cross-sectional study aimed to clarify the relationship between the SARC-F score and the extracellular water-to-total body water ratio (ECW/TBW) in community-dwelling older people.</p><p><strong>Methods: </strong>This study included 167 community-dwelling older people (aged ≥ 65) who were able to walk independently and used the SARC-F as a screening test for sarcopenia diagnosis. ECW/TBW and the skeletal muscle mass index (SMI) were measured using bioelectrical impedance analysis. The associations among the SARC-F score, ECW/TBW, and SMI were assessed using Spearman's correlation coefficient. Multiple linear regression analyses of the SARC-F score were conducted. Age, sex, number of medications, pain, medical history, ECW/TBW, and SMI were considered independent variables in multiple linear regression analysis.</p><p><strong>Results: </strong>The analyses revealed a significant positive correlation between the SARC-F score and ECW/TBW (ρ = 0.473, p < 0.001). SMI was significantly and negatively correlated with the SARC-F score (ρ = -0.233, p = 0.002). In the multiple linear regression analysis, ECW/TBW (β = 0.311, p < 0.001) and prevalence of pain (β = 0.169, p = 0.023) were significantly and independently associated with the SARC-F score (R<sup>2</sup> = 0.260). SMI was not significantly associated with the SARC-F score (β = 0.002, p = 0.986).</p><p><strong>Conclusion: </strong>This study revealed a positive correlation between SARC-F score and ECW/TBW in community-dwelling older people, and this relationship persisted even after adjusting for confounding factors. However, there was no correlation between the SARC-F score and SMI. Our study indicated that the SARC-F score may be considered an indirect indicator of ECW/TBW. The score might also be useful for discriminating high and low ECW/TBW. These findings highlight a new use for SARC-F.</p>\",\"PeriodicalId\":10352,\"journal\":{\"name\":\"Clinical nutrition ESPEN\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-11-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical nutrition ESPEN\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.clnesp.2024.11.015\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nutrition ESPEN","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.clnesp.2024.11.015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
The SARC-F score may indirectly reflect the extracellular water-to-total body water ratio.
Background & aims: In the Asian Working Group for Sarcopenia 2019 guidelines, SARC-F is used to screen for sarcopenia. SARC-F is measured based on five components: strength, assistance with walking, rising from a chair, climbing stairs, and falling. However, it has been reported that SARC-F has high specificity but low sensitivity for sarcopenia screening. Considering that SARC-F is currently recommended for sarcopenia screening, indicating the utility of SARC-F not only in sarcopenia screening but also in other aspects is pivotal. This cross-sectional study aimed to clarify the relationship between the SARC-F score and the extracellular water-to-total body water ratio (ECW/TBW) in community-dwelling older people.
Methods: This study included 167 community-dwelling older people (aged ≥ 65) who were able to walk independently and used the SARC-F as a screening test for sarcopenia diagnosis. ECW/TBW and the skeletal muscle mass index (SMI) were measured using bioelectrical impedance analysis. The associations among the SARC-F score, ECW/TBW, and SMI were assessed using Spearman's correlation coefficient. Multiple linear regression analyses of the SARC-F score were conducted. Age, sex, number of medications, pain, medical history, ECW/TBW, and SMI were considered independent variables in multiple linear regression analysis.
Results: The analyses revealed a significant positive correlation between the SARC-F score and ECW/TBW (ρ = 0.473, p < 0.001). SMI was significantly and negatively correlated with the SARC-F score (ρ = -0.233, p = 0.002). In the multiple linear regression analysis, ECW/TBW (β = 0.311, p < 0.001) and prevalence of pain (β = 0.169, p = 0.023) were significantly and independently associated with the SARC-F score (R2 = 0.260). SMI was not significantly associated with the SARC-F score (β = 0.002, p = 0.986).
Conclusion: This study revealed a positive correlation between SARC-F score and ECW/TBW in community-dwelling older people, and this relationship persisted even after adjusting for confounding factors. However, there was no correlation between the SARC-F score and SMI. Our study indicated that the SARC-F score may be considered an indirect indicator of ECW/TBW. The score might also be useful for discriminating high and low ECW/TBW. These findings highlight a new use for SARC-F.
期刊介绍：
Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.
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