应用静水压可上调成骨细胞球体内的 sost 基因表达。

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-11-18 DOI:10.1093/bbb/zbae165

Jeonghyun Kim, Kotone Niioka, Eijiro Maeda, Takeo Matsumoto

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引用次数: 0

摘要

在这项研究中，我们开发了一种静水加压室，能够对小鼠成骨细胞 MC3T3-E1 衍生的成骨细胞球体施加静水压力。我们的研究结果表明，在 200 kPa 的静水压下暴露 4 小时并不会改变球体的表观形态。然而，基因表达分析表明，晚期成骨细胞分化的标志物 Sost 有明显的上调。

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Application of hydrostatic pressure up-regulates sost gene expression in osteocytic spheroids.

In this study, we developed a hydrostatic pressurizing chamber capable of applying hydrostatic pressure to osteocytic spheroids derived from mouse osteoblastic MC3T3-E1 cells. Our results demonstrate that a 4-hour exposure to 200 kPa of hydrostatic pressure did not alter the apparent morphology of the spheroids. However, gene expression analysis revealed a significant up-regulation of Sost, marker of late-stage osteocyte differentiation.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).