利用稳定自由基作为 "电子供体"，开发用于高效 I 型光动力疗法的自由基光敏剂。

IF 12.2 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Materials Horizons Pub Date : 2024-11-19 DOI:10.1039/d4mh00952e

Xiao Cui, Fang Fang, Huan Chen, Chen Cao, Yafang Xiao, Shuang Tian, Jinfeng Zhang, Shengliang Li, Chun-Sing Lee

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引用次数: 0

摘要

在 I 型光敏剂中，稳定的有机自由基是克服缺氧的光动力疗法的理想候选分子。然而，复杂的制备过程和较差的稳定性限制了它们的广泛应用。在此，我们通过引入市售的 "TEMPO "分子，简单地合成了一种亚硝基自由基。该自由基在缺氧条件下具有高效的 I 型 ROS 生成能力和明显的光毒性，为探索新型高效 I 型光敏剂开辟了一条新途径。

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Using a stable radical as an "electron donor" to develop a radical photosensitizer for efficient type-I photodynamic therapy.

Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. However, their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available "TEMPO" moiety. The radical exhibits efficient type-I ROS generation and appreciable photo-cytotoxicity under hypoxia, which open up a new avenue for the exploration of a novel and efficient type-I photosensitizer.

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来源期刊

Materials Horizons CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

18.90

自引率

2.30%

发文量

306

审稿时长

1.3 months

期刊介绍： Materials Horizons is a leading journal in materials science that focuses on publishing exceptionally high-quality and innovative research. The journal prioritizes original research that introduces new concepts or ways of thinking, rather than solely reporting technological advancements. However, groundbreaking articles featuring record-breaking material performance may also be published. To be considered for publication, the work must be of significant interest to our community-spanning readership. Starting from 2021, all articles published in Materials Horizons will be indexed in MEDLINE©. The journal publishes various types of articles, including Communications, Reviews, Opinion pieces, Focus articles, and Comments. It serves as a core journal for researchers from academia, government, and industry across all areas of materials research. Materials Horizons is a Transformative Journal and compliant with Plan S. It has an impact factor of 13.3 and is indexed in MEDLINE.