碘化阴离子可实现还原性交叉亲电偶联，从而制备叔胺。

IF 16.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2024-11-19 DOI:10.1002/anie.202409688

Miran Lemmerer, Veronica Tona, David Just, Miloš Vavrík, Boris Maryasin, Giovanni Di Mauro, Andreas B Zur Bonsen, Daniel Kaiser, Nuno Maulide

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引用次数: 0

摘要

碘阴离子的还原能力是一种尚未被充分开发的特性，可用于有机分子的交叉亲电偶联。在本文中，我们利用这一特性，通过两种简单试剂的组合制备叔胺：亲电碳前体和碘化亚胺的双重作用--既是含氮结构单元，又是还原剂。通过实验和量子化学计算的结合，探索了这种新的 C-C 键形成模式的基本机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Iodide anion enables a reductive cross-electrophile coupling for preparing tertiary amines.

The reducing power of iodide anion is an underexplored property that can be used for the cross-electrophile coupling of organic molecules. Herein we harness this trait for the preparation of tertiary amines through the combination of two simple reagents: an electrophilic-carbon precursor and an iminium iodide in a dual role-both as nitrogen-containing building block and as reducing agent. The underlying mechanism of this new C-C bond-formation paradigm is explored through a combination of experiment and quantum chemical calculations.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.