{"title":"封面：2-氨基-6-乙烯基-7-脱氮嘌呤脱氧核苷在 RNA 中的尿嘧啶选择性交联和对 miRNA 功能的抑制（ChemBioChem 21/2024）","authors":"Nadya Soemawisastra, Hidenori Okamura, Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Mamiko Ozawa, Fumi Nagatsugi","doi":"10.1002/cbic.202482101","DOIUrl":null,"url":null,"abstract":"<p>MicroRNAs (miRNAs) regulate gene expression through RNA interference. Consequently, miRNA inhibitors, such as anti-miRNA oligonucleotides (AMOs), have attracted attention for treating miRNA overexpression. In article 10.1002/cbic.202400417, Fumi Nagatsugi and co-workers demonstrate that the cross-linkable nucleoside (2-amino-7-deaza-7-propynyl-6-vinylpurine deoxyriboside; dADpVP) reacted to counter uridine with high reactivity upon duplex hybridization. Moreover, the oligonucleotide containing dADpVP targeting the miRNA binding site in mRNA 3′UTR effectively inhibit the miR21 function in cells by covalent formation.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":"25 21","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.202482101","citationCount":"0","resultStr":"{\"title\":\"Front Cover: Uracil-Selective Cross-Linking in RNA and Inhibition of miRNA Function by 2-Amino-6-vinyl-7-deazapurine Deoxynucleosides (ChemBioChem 21/2024)\",\"authors\":\"Nadya Soemawisastra, Hidenori Okamura, Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Mamiko Ozawa, Fumi Nagatsugi\",\"doi\":\"10.1002/cbic.202482101\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>MicroRNAs (miRNAs) regulate gene expression through RNA interference. Consequently, miRNA inhibitors, such as anti-miRNA oligonucleotides (AMOs), have attracted attention for treating miRNA overexpression. In article 10.1002/cbic.202400417, Fumi Nagatsugi and co-workers demonstrate that the cross-linkable nucleoside (2-amino-7-deaza-7-propynyl-6-vinylpurine deoxyriboside; dADpVP) reacted to counter uridine with high reactivity upon duplex hybridization. Moreover, the oligonucleotide containing dADpVP targeting the miRNA binding site in mRNA 3′UTR effectively inhibit the miR21 function in cells by covalent formation.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure>\\n </p>\",\"PeriodicalId\":140,\"journal\":{\"name\":\"ChemBioChem\",\"volume\":\"25 21\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.202482101\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemBioChem\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cbic.202482101\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbic.202482101","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Front Cover: Uracil-Selective Cross-Linking in RNA and Inhibition of miRNA Function by 2-Amino-6-vinyl-7-deazapurine Deoxynucleosides (ChemBioChem 21/2024)
MicroRNAs (miRNAs) regulate gene expression through RNA interference. Consequently, miRNA inhibitors, such as anti-miRNA oligonucleotides (AMOs), have attracted attention for treating miRNA overexpression. In article 10.1002/cbic.202400417, Fumi Nagatsugi and co-workers demonstrate that the cross-linkable nucleoside (2-amino-7-deaza-7-propynyl-6-vinylpurine deoxyriboside; dADpVP) reacted to counter uridine with high reactivity upon duplex hybridization. Moreover, the oligonucleotide containing dADpVP targeting the miRNA binding site in mRNA 3′UTR effectively inhibit the miR21 function in cells by covalent formation.
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ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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