自身炎症性疾病中的皮脑对话：生物标志物的新途径？

IF 3.7 Q2 IMMUNOLOGY

Brain, behavior, & immunity - health Pub Date : 2024-11-09 DOI:10.1016/j.bbih.2024.100906

S. Matar , S. Aractingi , R. Gaillard , A.-C. Petit

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引用次数: 0

摘要

自身炎症性疾病（AID）是一种罕见的全身性炎症性疾病，是由于单基因或多基因先天性免疫功能障碍所致。它们影响许多器官，包括大脑和皮肤。由于新开发的诊断工具的出现，这类疾病的范围近来迅速扩大。神经-免疫-内分泌-皮肤之间的相互作用在这些疾病的病理生理学中起着重要作用。在 AID 中，皮肤与大脑之间的相互作用尚未得到充分研究，支持双向交流的证据也未得到审查。本文概述了具有皮肤和精神表现的 AID 的病理生理学现状。阐明 AID 病理生理学背后的神经-免疫-内分泌-皮肤失调，对于确定未来的生物标记物和治疗方案大有希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Skin-brain dialogue in auto-inflammatory diseases: A new route to biomarkers?

Autoinflammatory diseases (AID) are rare systemic inflammatory disorders due to monogenic or polygenic dysfunction of innate immunity. They affect many organs including the brain and the skin. The spectrum of these diseases has been rapidly expanding recently due to newly developed diagnostic tools. The neuro-immuno-endocrine-cutaneous interactions play an important role in the pathophysiology of these diseases. The skin-brain interplay is not fully investigated in AID and evidence supporting bidirectional communication is examined. This article provides an overview of the current state of the art in the pathophysiology of AID with cutaneous and psychiatric manifestations. Elucidating the neuro-immuno-endocrine-cutaneous dysregulation underlying pathophysiology of AID is promising for determining future biomarkers and therapeutic options.

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来源期刊

Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience

CiteScore

8.50

自引率

0.00%

发文量

审稿时长

97 days