石榴与洗必泰漱口水或凝胶对牙周病的影响：系统回顾与荟萃分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2024-10-21 DOI:10.1016/j.hermed.2024.100955

Roghayeh Javan , Zahra Baghani , Elaheh Foroumandi

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The effect of pomegranate versus chlorhexidine mouthwash or gel on periodontal disease: a systematic review and meta-analysis

Objective

The aim of current systematic review and meta-analysis study was to evaluate the effect of pomegranate (POM) versus Chlorhexidine (CHX) mouthwashes or gels on periodontal disease.

Methods

An electronic search on PubMed, Scopus, Science direct, and Cochrane, as well as manual search was conducted on the studies that were published up until August 2023. Randomised controlled trials studies that had examined the effect of POM versus CHX mouthwash or gel on plaque (PI), gingival (GI), and bleeding (BI) indices after 7 and 14–15 days follow up with 95% confidence interval (CI) were pooled. To assess the heterogeneity of the findings, the I² test was applied and also publication bias was evaluated by visual examination of the funnel plot symmetry.

Results

Seven studies with 330 participants were analyzed. The meta-analysis showed that there was a significant difference between the effects of CHX intervention on PI compared to POM intervention, when the duration of intervention was 14–15 days (standard mean differences [SMD]: −2.25; 95% CI: −4.18 to −0.32, P = 0.02). There was not any significant difference among the effects of CHX and POM intervention on PI when the study duration was up to 7 days. Further, there was not seen any significant differences between the effects of POM and CHX on BI or GI of the subjects.

Conclusion

The findings indicated that POM mouthwashes or gel were effective in reducing PI, BI, and GI in patients with periodontal disease. Therefore, it can be suggested as a suitable alternative of CHX for inflammation control.

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来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.