个性化和适应性戒烟干预：新趋势和疗效的决定因素

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2024-11-15 DOI:10.1016/j.isci.2024.111090

Gal Cohen , Carlo Maria Bellanca , Renato Bernardini , Jed E. Rose , Riccardo Polosa

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引用次数: 0

摘要

吸烟成瘾是发病和死亡的主要原因，也是一个具有挑战性的干预目标。戒烟干预在替代或减弱香烟效应的能力方面需要权衡利弊，香烟效应包括正强化和负强化、心理奖励、厌恶感和感官享受，这些效应通过尼古丁和非尼古丁的吸烟因素进行调节。现有疗法包括尼古丁替代疗法（NRTs）、伐尼克兰和安非他酮，而胞二磷胆碱和尼古丁替代产品的证据基础也在不断扩大，更多快速起效的尼古丁替代疗法即将问世，所有这些都在扩大个人的选择范围。了解疗效的决定因素可以为个性化和适应性戒烟方法提供依据，这为进一步改善戒烟效果提供了机会。这包括根据个人对一线干预的最初反应、偏好和耐受性来定制戒烟治疗计划，并在需要时考虑二线选择（包括循证联合疗法）。视频摘要下载：下载视频 (61MB)

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Personalized and adaptive interventions for smoking cessation: Emerging trends and determinants of efficacy

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Personalized and adaptive interventions for smoking cessation: Emerging trends and determinants of efficacy

Cigarette smoking addiction is a leading cause of morbidity and mortality and presents a challenging interventional target. Interventions for stopping smoking offer trade-offs in ability to displace or blunt the effects of cigarettes, which include positive and negative reinforcement, psychological reward, aversiveness, and sensory enjoyment, and which are mediated through nicotine and non-nicotine elements of smoking. Established therapies, which include nicotine replacement therapies (NRTs), varenicline, and bupropion are being supplemented with a growing evidence base for cytisine and nicotine substitution products, with more rapid acting NRTs on the horizon, all of which are expanding individual choice. An understanding of determinants of efficacy can inform a personalized and adaptive approach to smoking cessation, which presents an opportunity to further improve outcomes. This includes tailoring cessation treatment plans based on initial individual response, preference, and tolerability to first line interventions and considering second-line options (including evidence-based combination therapies) when needed.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

期刊介绍： Science has many big remaining questions. To address them, we will need to work collaboratively and across disciplines. The goal of iScience is to help fuel that type of interdisciplinary thinking. iScience is a new open-access journal from Cell Press that provides a platform for original research in the life, physical, and earth sciences. The primary criterion for publication in iScience is a significant contribution to a relevant field combined with robust results and underlying methodology. The advances appearing in iScience include both fundamental and applied investigations across this interdisciplinary range of topic areas. To support transparency in scientific investigation, we are happy to consider replication studies and papers that describe negative results. We know you want your work to be published quickly and to be widely visible within your community and beyond. With the strong international reputation of Cell Press behind it, publication in iScience will help your work garner the attention and recognition it merits. Like all Cell Press journals, iScience prioritizes rapid publication. Our editorial team pays special attention to high-quality author service and to efficient, clear-cut decisions based on the information available within the manuscript. iScience taps into the expertise across Cell Press journals and selected partners to inform our editorial decisions and help publish your science in a timely and seamless way.