金钗石斛中的生物碱及其抗炎活性

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-11-11 DOI:10.1016/j.phytol.2024.11.003

Zao-Yu Xu , Chao-Fan Wang , Wen Li , Nan Fu , Rui Zhan

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引用次数: 0

摘要

为了鉴定抗炎生物碱，我们研究了金钗石斛（Dendrobium nobile Lindl.从氯仿提取物中分离出了 13 种生物碱，其中包括一种新生物碱，并利用光谱方法确定了它们的结构。生物测定评估了这些分离物的抗炎活性。化合物 1 和 9 能抑制 LPS 激活的 RAW264.7 巨噬细胞产生一氧化氮，其 IC50 值分别为 16.7 μM 和 24.4 μM。

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Alkaloids from Dendrobium nobile and their anti-inflammatory activities

To identify anti-inflammatory alkaloids, we investigated the aerial parts of cultivated Dendrobium nobile Lindl. Thirteen alkaloids, including a new one, were isolated from the chloroform extract, and their structures were determined using spectroscopic methods. Bioassays assessed the anti-inflammatory activities of these isolates. Compounds 1 and 9 demonstrated inhibition of nitric oxide production in LPS-activated RAW264.7 macrophages, with IC₅₀ values of 16.7 μM and 24.4 μM, respectively.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.