Pengli Su , Kai Zhi , Haixia Dang , Huanhuan Xu , Jing Xiao , Jun Liu , Zhong Wang , Yanan Yu
{"title":"评估丹红注射液治疗慢性稳定型心绞痛的整体价值:中国的多标准决策分析","authors":"Pengli Su , Kai Zhi , Haixia Dang , Huanhuan Xu , Jing Xiao , Jun Liu , Zhong Wang , Yanan Yu","doi":"10.1016/j.hermed.2024.100957","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to assess the holistic value of Danhong injection (DHI) for treating chronic stable angina (CSA) and to identify the therapeutic characteristics of DHI.</div></div><div><h3>Methods</h3><div>The holistic value of DHI was assessed using a well-established evaluation index system including 34 criteria based on the Multi-criteria decision analysis (MCDA) model. Each criterion was rated by seven experts based on an evidence matrix comprising a literature review on DHI for treating CSA. The overall value of DHI for the treatment of CSA was evaluated by aggregating these performance scores and predetermined weights. Additionally, the contributions of each domain and criterion to the overall value estimate were calculated. Uncertainty was explored using an online retest and intra-rater correlation coefficient (ICC).</div></div><div><h3>Results</h3><div>We found that the comprehensive value estimate of DHI for treating CSA was 80.18 points. The domain of “safety and risk management” was the strongest contributor to the final estimated value (30.37), followed by “effectiveness” (23.75). The criteria “size of population affected by disease” (3.79), “risk control of toxic medicinal materials” (4.38), “comparative non-medical costs” (1.14), “clarity of the mechanism of drug action” (0.6), “sustainability of medicinal materials resources” (1.91) and “patient compliance” (4.59) were found to be the most significant contributors to the overall value estimate across the 6 evaluation domains. The initial scores for DHI over the two rounds showed good consistency across panelists (ICC<!--> <!-->=<!--> <!-->0.886 [0.858–0.909]).</div></div><div><h3>Conclusion</h3><div>Compared with standard treatment alone, DHI was perceived as being at a “good level” intervention.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100957"},"PeriodicalIF":2.2000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessing the holistic value of Danhong injection for chronic stable angina: a multi-criteria decision analysis in China\",\"authors\":\"Pengli Su , Kai Zhi , Haixia Dang , Huanhuan Xu , Jing Xiao , Jun Liu , Zhong Wang , Yanan Yu\",\"doi\":\"10.1016/j.hermed.2024.100957\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>This study aimed to assess the holistic value of Danhong injection (DHI) for treating chronic stable angina (CSA) and to identify the therapeutic characteristics of DHI.</div></div><div><h3>Methods</h3><div>The holistic value of DHI was assessed using a well-established evaluation index system including 34 criteria based on the Multi-criteria decision analysis (MCDA) model. Each criterion was rated by seven experts based on an evidence matrix comprising a literature review on DHI for treating CSA. The overall value of DHI for the treatment of CSA was evaluated by aggregating these performance scores and predetermined weights. Additionally, the contributions of each domain and criterion to the overall value estimate were calculated. Uncertainty was explored using an online retest and intra-rater correlation coefficient (ICC).</div></div><div><h3>Results</h3><div>We found that the comprehensive value estimate of DHI for treating CSA was 80.18 points. The domain of “safety and risk management” was the strongest contributor to the final estimated value (30.37), followed by “effectiveness” (23.75). The criteria “size of population affected by disease” (3.79), “risk control of toxic medicinal materials” (4.38), “comparative non-medical costs” (1.14), “clarity of the mechanism of drug action” (0.6), “sustainability of medicinal materials resources” (1.91) and “patient compliance” (4.59) were found to be the most significant contributors to the overall value estimate across the 6 evaluation domains. The initial scores for DHI over the two rounds showed good consistency across panelists (ICC<!--> <!-->=<!--> <!-->0.886 [0.858–0.909]).</div></div><div><h3>Conclusion</h3><div>Compared with standard treatment alone, DHI was perceived as being at a “good level” intervention.</div></div>\",\"PeriodicalId\":56077,\"journal\":{\"name\":\"Journal of Herbal Medicine\",\"volume\":\"48 \",\"pages\":\"Article 100957\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Herbal Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210803324001143\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbal Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210803324001143","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Assessing the holistic value of Danhong injection for chronic stable angina: a multi-criteria decision analysis in China
Introduction
This study aimed to assess the holistic value of Danhong injection (DHI) for treating chronic stable angina (CSA) and to identify the therapeutic characteristics of DHI.
Methods
The holistic value of DHI was assessed using a well-established evaluation index system including 34 criteria based on the Multi-criteria decision analysis (MCDA) model. Each criterion was rated by seven experts based on an evidence matrix comprising a literature review on DHI for treating CSA. The overall value of DHI for the treatment of CSA was evaluated by aggregating these performance scores and predetermined weights. Additionally, the contributions of each domain and criterion to the overall value estimate were calculated. Uncertainty was explored using an online retest and intra-rater correlation coefficient (ICC).
Results
We found that the comprehensive value estimate of DHI for treating CSA was 80.18 points. The domain of “safety and risk management” was the strongest contributor to the final estimated value (30.37), followed by “effectiveness” (23.75). The criteria “size of population affected by disease” (3.79), “risk control of toxic medicinal materials” (4.38), “comparative non-medical costs” (1.14), “clarity of the mechanism of drug action” (0.6), “sustainability of medicinal materials resources” (1.91) and “patient compliance” (4.59) were found to be the most significant contributors to the overall value estimate across the 6 evaluation domains. The initial scores for DHI over the two rounds showed good consistency across panelists (ICC = 0.886 [0.858–0.909]).
Conclusion
Compared with standard treatment alone, DHI was perceived as being at a “good level” intervention.
期刊介绍:
The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.