接种冠状病毒病（COVID-19）疫苗后贝尔麻痹的发病率：系统回顾和荟萃分析

IF 2.9 4区医学 Q2 CLINICAL NEUROLOGY

Neurologia Pub Date : 2024-11-01 DOI:10.1016/j.nrl.2022.10.002

Atena Soltanzadi , Omid Mirmosayyeb , Amin Momeni Moghaddam , Hamed Ghoshouni , Mahsa Ghajarzadeh

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引用次数: 0

摘要

方法由两名独立研究人员检索了PubMed、Scopus、EMBASE、Web of Science和Google Scholar。我们还检索了灰色文献，包括参考文献和会议摘要。我们提取了有关参与者总数、第一作者、发表年份、来源国、性别、疫苗类型以及接种 COVID-19 疫苗后出现贝尔氏麻痹的患者人数的数据。对全文进行仔细评估后，剩下 20 篇文章用于荟萃分析。最常接种的疫苗是辉瑞公司的疫苗，其次是 Moderna 公司的疫苗。共有 4.54e+07 人接种了 COVID-19 疫苗，其中 1739 例出现了贝尔氏麻痹。在九项研究中，对照组（未接种疫苗者）也被纳入其中。对照组总人数为 1 809 069 人，其中 203 人患贝尔麻痹。接种 COVID-19 疫苗后，贝尔氏麻痹的发病率可忽略不计。接种 COVID-19 疫苗后发生贝尔氏麻痹的几率为 1.02 (95% CI: 0.79-1.32) (I2 = 74.8%, P < .001)。也许，贝尔氏麻痹是更严重形式的 COVID-19 的一种表现症状，因此临床医生必须注意这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Incidence of Bell’s palsy after coronavirus disease (COVID-19) vaccination: a systematic review and meta-analysis

Objective

To estimate the pooled incidence of Bell’s palsy after COVID-19 vaccination.

Methods

PubMed, Scopus, EMBASE, Web of Science, and Google Scholar were searched by 2 independent researchers. We also searched the grey literature including references of the references and conference abstracts. We extracted data regarding the total number of participants, first author, publication year, the country of origin, sex, type of vaccines, and the number of patients who developed Bell’s palsy after COVID-19 vaccination.

Results

The literature search revealed 370 articles, subsequently deleting duplicates 227 remained. After careful evaluation of the full texts, 20 articles remained for meta-analysis. The most commonly administered vaccines were Pfizer followed by Moderna.

In total, 4.54e+07 individuals received vaccines against COVID-19, and 1739 cases developed Bell’s palsy. In nine studies, controls (individuals without vaccination) were enrolled. The total number of controls was 1 809 069, of whom 203 developed Bell’s palsy. The incidence of Bell’s palsy after COVID-19 vaccines was ignorable. The odds of developing Bell’s palsy after COVID-19 vaccines was 1.02 (95% CI: 0.79-1.32) (I2 = 74.8%, P < .001).

Conclusion

The results of this systematic review and meta-analysis show that the incidence of peripheral facial palsy after COVID-19 vaccination is ignorable and vaccination does not increase the risk of developing Bell’s palsy. Maybe, Bell’s palsy is a presenting symptom of a more severe form of COVID-19, so clinicians must be aware of this.

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.