BDNF 介导的 GSK-3β 和 PSD95 磷酸化调控对 Capsosiphon fulvescens 糖蛋白抗慢性酒精暴露的抑郁作用

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2024-11-16 DOI:10.1016/j.jff.2024.106571

Jeong Hwan Oh, Taek-Jeong Nam

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引用次数: 0

摘要

来自藻类 Capsosiphon fulvescens 的亲水性糖蛋白（Cf-hGP）能增强衰老大鼠的空间记忆并减少其抑郁样行为。然而，它们对乙醇诱导的青少年大鼠抑郁样行为的影响及其内在机制仍不清楚。本研究调查了 Cf-hGP 对减轻大鼠慢性酒精摄入（2 克/公斤，4 周）引起的抑郁样行为的神经保护作用，重点研究了腹侧海马的分子变化。慢性酒精暴露增加了葡萄糖调节蛋白 78（ER 应激标记物），同时降低了脑源性神经营养因子（BDNF）、糖原合酶激酶 3-β（GSK-3β；Ser9）和突触后密度蛋白 95（PSD95；Ser295）的磷酸化。服用Cf-hGP（10 mg/kg/d）可逆转这些影响，恢复GSK-3β和PSD95的磷酸化。BDNF信号传导的阻断抑制了Cf-hGP的作用，证实了它在BDNF介导的神经保护中的作用。Cf-hGP还能减少酒精诱发的抑郁样行为，这表明它有可能通过调节ER应激和BDNF信号通路成为酒精诱发抑郁的治疗药物。

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BDNF-mediated regulation of GSK-3β and PSD95 phosphorylation in anti-depressive effects of Capsosiphon fulvescens glycoproteins against chronic alcohol exposure

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BDNF-mediated regulation of GSK-3β and PSD95 phosphorylation in anti-depressive effects of Capsosiphon fulvescens glycoproteins against chronic alcohol exposure

Hydrophilic glycoproteins from the alga Capsosiphon fulvescens (Cf-hGP) enhance spatial memory and reduce depression-like behavior in aging rats. However, their effects on ethanol-induced depression-like behavior in adolescent rats and underlying mechanisms remain unclear. This study investigated the neuroprotective effects of Cf-hGP in mitigating depression-like behavior caused by chronic alcohol administration (2 g/kg, 4 weeks) in rats, focusing on molecular changes in the ventral hippocampus. Chronic alcohol exposure increased glucose-regulated protein 78 (an ER stress marker), while decreasing brain-derived neurotrophic factor (BDNF) and phosphorylation of glycogen synthase kinase 3-beta (GSK-3β; Ser9) and postsynaptic density protein 95 (PSD95; Ser295). Cf-hGP administration (10 mg/kg/d) reversed these effects, restoring GSK-3β and PSD95 phosphorylation. Blockade of BDNF signaling suppressed Cf-hGP’s effects, confirming its role in BDNF-mediated neuroprotection. Cf-hGP also reduced alcohol-induced depression-like behavior, suggesting its potential as a therapeutic agent for alcohol-induced depression via modulation of ER stress and BDNF signaling pathways.

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.