华中地区儿童和青少年维生素 D 缺乏症的高流行率和季节性模式:一项为期三年的单中心研究

IF 2.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Lei Xi , Xiaomei Wang , Jingjing Rao, Ye Zeng, Yun Xiang, Changzhen Li
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引用次数: 0

摘要

方法 从2019年1月至2022年2月,在一家儿童医院共招募了8248名0-18岁的儿童和青少年,测量他们的血清维生素D水平,并收集每月的气象和空气污染数据。结果血清维生素D总平均水平为(37.7±17.7)纳克/毫升,维生素D缺乏率为17.7%,维生素D不足率为23.4%。13-18 岁儿童的维生素 D 缺乏率最高(64.1%),充足率最低(4.8%)。与男孩相比,女孩,尤其是 6-13 岁和 13-18 岁女孩的维生素 D 缺乏率更高。维生素 D 缺乏症发病率最高的是冬季(23.2%),最低的是秋季(12.0%)。维生素 D 不足在夏季最为普遍(27.0%),明显高于其他季节。在春季和夏季,女孩比男孩更容易缺乏维生素 D。逐步多元线性回归分析表明,维生素 D 水平、二氧化氮浓度和日照时间呈正相关,而与颗粒物 2.5(PM2.5)呈负相关。应采取的策略包括促进日照、减少空气污染,并考虑补充维生素 D,尤其是在春季和夏季。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High prevalence and seasonal patterns of vitamin D deficiency in children and adolescents in Central China: a three-year single-center study

Objective

This study aimed to determine the prevalence and associated factors of vitamin D deficiency and insufficiency in children and adolescents in Central China.

Methods

In total, 8,248 children and adolescents aged 0–18 years at a children’s hospital from January 2019 to February 2022, were recruited. Their serum vitamin D levels were measured, and monthly meteorological and air pollution data were collected.

Results

The overall mean serum vitamin D level was 37.7 ± 17.7 ng/mL, and the prevalence of vitamin D deficiency and insufficiency was 17.7 % and 23.4 %, respectively. Children aged 13–18 years had the highest vitamin D deficiency rate (64.1 %) and the lowest sufficiency rate (4.8 %). The incidence of vitamin D deficiency in girls, especially those aged 6–13 years and 13–18 years, was higher compared to boys. The highest prevalence of vitamin D deficiency was observed in winter (23.2 %), whereas the lowest was found in autumn (12.0 %). Vitamin D insufficiency was most prevalent in summer (27.0 %), significantly higher than in other seasons. Girls were more prone than boys to vitamin D deficiency in spring and summer. Stepwise multiple linear regression analysis showed a positive correlation between vitamin D levels, nitrogen dioxide concentrations, and sunshine hours and a negative correlation with particulate matter 2.5 (PM2.5).

Conclusion

Our study found high vitamin D deficiency among children in central China, especially girls aged 13–18. Strategies should include promoting sunlight, reducing air pollution, and considering supplementation, particularly in spring and summer.
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来源期刊
Preventive Medicine Reports
Preventive Medicine Reports Medicine-Public Health, Environmental and Occupational Health
CiteScore
3.90
自引率
0.00%
发文量
353
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