Tingting Niu , Yange Zhang , Shengqiang Liu , Shuntao Li , Hongtao Yang , Tongtong Lu , Yong Sun , Hongxia Sun , Youde Wang , Liying Zhang , Liqun Ren , Yu Jin , Tao Suo , Rui Zan , Yimin Wang , Guodong Zou , Carlos Fernandez , Qiuming Peng
{"title":"用于骨内固定的微合金镁基降解植入物","authors":"Tingting Niu , Yange Zhang , Shengqiang Liu , Shuntao Li , Hongtao Yang , Tongtong Lu , Yong Sun , Hongxia Sun , Youde Wang , Liying Zhang , Liqun Ren , Yu Jin , Tao Suo , Rui Zan , Yimin Wang , Guodong Zou , Carlos Fernandez , Qiuming Peng","doi":"10.1016/j.mtla.2024.102258","DOIUrl":null,"url":null,"abstract":"<div><div>The bottleneck for Mg-based degradable implants lies in the mismatching relationship between mechanical properties and degradable rate, resulting in the rapid failure during the <em>in-vivo</em> degradable process and potential toxic role. Herein microalloy-conception has been involved to rectify the equilibrium effects among several aspects. Microstructure, mechanical properties, degradable properties and <em>in-vitro/in-vivo</em> biocompatibility properties of as-extruded pure Mg, Mg-0.15Ca, and Mg-0.15Ca-0.10Mn samples have been investigated. The results show that the Mg-0.15Ca-0.1Mn alloy exhibits a high yield strength (110 MPa) and a low degradable rate (0.82 mm/y). Attractively, the mechanical integrity has been remained in Mg-0.15Ca-0.1Mn alloy after 14 weeks in the rat femoral mode, and a homogenous degradable rate with 0.92 mm/y has been confirmed, which is basically equivalent to the <em>in vitro</em> value. Simultaneously, the low concentration of ions also reveals satisfactory biocompatibility equal to pure Mg, based on organ function and pathological morphology. Our findings reveal that microalloy paves a possible route to design high performance Mg-based intra-osteal fixation implants, resolving the contradictions among the degradable requirements under different body environments.</div></div>","PeriodicalId":47623,"journal":{"name":"Materialia","volume":"38 ","pages":"Article 102258"},"PeriodicalIF":3.0000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microalloy Mg-based degradation implant for intra-osteal fixation\",\"authors\":\"Tingting Niu , Yange Zhang , Shengqiang Liu , Shuntao Li , Hongtao Yang , Tongtong Lu , Yong Sun , Hongxia Sun , Youde Wang , Liying Zhang , Liqun Ren , Yu Jin , Tao Suo , Rui Zan , Yimin Wang , Guodong Zou , Carlos Fernandez , Qiuming Peng\",\"doi\":\"10.1016/j.mtla.2024.102258\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The bottleneck for Mg-based degradable implants lies in the mismatching relationship between mechanical properties and degradable rate, resulting in the rapid failure during the <em>in-vivo</em> degradable process and potential toxic role. Herein microalloy-conception has been involved to rectify the equilibrium effects among several aspects. Microstructure, mechanical properties, degradable properties and <em>in-vitro/in-vivo</em> biocompatibility properties of as-extruded pure Mg, Mg-0.15Ca, and Mg-0.15Ca-0.10Mn samples have been investigated. The results show that the Mg-0.15Ca-0.1Mn alloy exhibits a high yield strength (110 MPa) and a low degradable rate (0.82 mm/y). Attractively, the mechanical integrity has been remained in Mg-0.15Ca-0.1Mn alloy after 14 weeks in the rat femoral mode, and a homogenous degradable rate with 0.92 mm/y has been confirmed, which is basically equivalent to the <em>in vitro</em> value. Simultaneously, the low concentration of ions also reveals satisfactory biocompatibility equal to pure Mg, based on organ function and pathological morphology. Our findings reveal that microalloy paves a possible route to design high performance Mg-based intra-osteal fixation implants, resolving the contradictions among the degradable requirements under different body environments.</div></div>\",\"PeriodicalId\":47623,\"journal\":{\"name\":\"Materialia\",\"volume\":\"38 \",\"pages\":\"Article 102258\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materialia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2589152924002552\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materialia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589152924002552","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Microalloy Mg-based degradation implant for intra-osteal fixation
The bottleneck for Mg-based degradable implants lies in the mismatching relationship between mechanical properties and degradable rate, resulting in the rapid failure during the in-vivo degradable process and potential toxic role. Herein microalloy-conception has been involved to rectify the equilibrium effects among several aspects. Microstructure, mechanical properties, degradable properties and in-vitro/in-vivo biocompatibility properties of as-extruded pure Mg, Mg-0.15Ca, and Mg-0.15Ca-0.10Mn samples have been investigated. The results show that the Mg-0.15Ca-0.1Mn alloy exhibits a high yield strength (110 MPa) and a low degradable rate (0.82 mm/y). Attractively, the mechanical integrity has been remained in Mg-0.15Ca-0.1Mn alloy after 14 weeks in the rat femoral mode, and a homogenous degradable rate with 0.92 mm/y has been confirmed, which is basically equivalent to the in vitro value. Simultaneously, the low concentration of ions also reveals satisfactory biocompatibility equal to pure Mg, based on organ function and pathological morphology. Our findings reveal that microalloy paves a possible route to design high performance Mg-based intra-osteal fixation implants, resolving the contradictions among the degradable requirements under different body environments.
期刊介绍:
Materialia is a multidisciplinary journal of materials science and engineering that publishes original peer-reviewed research articles. Articles in Materialia advance the understanding of the relationship between processing, structure, property, and function of materials.
Materialia publishes full-length research articles, review articles, and letters (short communications). In addition to receiving direct submissions, Materialia also accepts transfers from Acta Materialia, Inc. partner journals. Materialia offers authors the choice to publish on an open access model (with author fee), or on a subscription model (with no author fee).