金属酞菁复合材料作为光敏剂在光动力疗法中的机遇与挑战：综述

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications Pub Date : 2024-11-06 DOI:10.1016/j.inoche.2024.113491

Keshavananda Prabhu Channabasavana Hundi Puttaningaiah, Jaehyun Hur

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引用次数: 0

摘要

光动力疗法（PDT）是一种治疗各种疾病（包括癌细胞发展、污染和微生物感染）的有效方法。金属酞菁（MPcs）因其化学和光物理特性以及易于官能化的特点，已成为光动力疗法的主要光敏剂（PSs）。本综述探讨了 MPc 的机遇与挑战，以及它们在光激活时产生活性氧并诱导靶细胞产生细胞毒性效应的关键作用。我们研究了多晶锰酸锂的光物理特性、它们在光透射疗法中的作用，以及它们的适用性参数，如溶解度、生物分布和对病变组织的选择性。为了扩大光导放疗的可行性，我们研究了 MPc 复合材料的设计和合成方面的最新进展，包括将它们整合到纳米载体中以及用靶向配体进行功能化。这些创新旨在提高光导放疗的特异性和效率，同时将脱靶效应降至最低。此外，本综述还将基于 MPc 的光导疗法与传统疗法进行了比较，强调了其作为增强光导疗法活性的先进方法的潜在应用。最后，本研究确定了未来的研究方向和技术创新，以优化 MPc 复合材料在光紫外疗法中的临床应用，强调了它们作为 PS 的现状和前景，并强调了它们在推动光紫外疗法成为现代医学中一种有针对性的有效治疗方法中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Opportunities and challenges of metal phthalocyanines composites in photodynamic therapy as photosensitizers: A comprehensive review

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Opportunities and challenges of metal phthalocyanines composites in photodynamic therapy as photosensitizers: A comprehensive review

Photodynamic therapy (PDT) is a promising treatment for various diseases, including cancer cell development, contamination, and microbial infections. Metal phthalocyanines (MPcs) have emerged as prominent photosensitizers (PSs) for PDT owing to their chemical and photophysical properties and ease of functionalization. This comprehensive review explores the opportunities and challenges of MPc and their crucial role in generating reactive oxygen species upon light activation, which induces cytotoxic effects in targeted cells. We examined the photophysical properties of MPc, their action in PDT, and their suitability parameters, such as solubility, biodistribution, and selectivity for diseased tissues. To extend PDT feasibility, we examined recent advancements in the design and synthesis of MPc composites, including their integration into nanocarriers and functionalization with targeting ligands. These innovations aim to enhance PDT specificity and efficiency while minimizing off-target effects. Additionally, this review compares MPc-based PDT to conventional therapies, highlighting its potential application as an advanced approach to enhancing PDT activity. Finally, this study identifies the future research directions and technological innovations necessary to optimize the clinical translation of MPc composites in PDT, highlighting their current state and prospects as PSs and emphasizing their role in advancing PDT as a targeted and effective therapeutic approach in modern medicine.

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来源期刊

Inorganic Chemistry Communications 化学-无机化学与核化学

CiteScore

5.50

自引率

7.90%

发文量

1013

审稿时长

53 days

期刊介绍： Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.