纳米级 Janus 粒子的制造和超分辨率显微镜的直接观察

IF 4.9 2区 化学 Q2 CHEMISTRY, PHYSICAL
Noga Yaakov , Raz Cohen , Yogapriya Ravi , Karthik Ananth Mani , Idan Harush , Tali Dadosh , Olga Brontvein , Einat Zelinger , Guy Mechrez
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引用次数: 0

摘要

我们开发了一种新的简便方法,用于合成、标记和表征两亲性纳米级 Janus 粒子。通过反溶剂置换法将 Aerodisp W1226 气相法二氧化硅颗粒的水分散液嵌入聚碳酸酯(P.C.)微球表面,并通过胺基团进一步初级官能化。随后,溶解聚合物,再进行第二次改性,在颗粒显露的嵌入侧引入硫醇基团,形成硅基 Janus/亲水颗粒。我们首先用激光扫描共聚焦显微镜对 Janus 粒子进行了表征,然后用直接随机光学重建显微镜(dSTORM)检测了不同官能团的标记分布。超分辨成像结果证实,制备的粒子是每个半球具有不同化学性质的 Janus 粒子。此外,还利用扫描和透射电子显微镜对颗粒的尺寸和形状进行了表征。结果显示,非球面颗粒有两个半球,证实了制备和化学修饰的成功。此外,这项工作还成功地展示了纳米级 Janus/亲水粒子纳米级 Janus 粒子的合成、表征和分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanoscale Janus particle fabrication and direct observation by super-resolution microscopy
We have developed a new and facile approach for synthesis, labeling, and characterizing amphiphilic nanoscale Janus particles. The aqueous dispersion of the Aerodisp W1226 fumed silica particles were embedded into polycarbonate (P.C.) microspheres surfaces via inverse solvent displacement method and further primary functionalization by an amine group. Subsequently, the polymer was dissolved, and a second modification was preferred to introduce a thiol group on the revealed embedded side of the particles, forming silica-based Janus/amphiphilic particles. We first characterized the Janus particles by laser scanning confocal microscopy and then with direct stochastic optical reconstruction microscopy (dSTORM) to detect the labeling distribution of the different functional groups. Super-resolution imaging results confirmed that the fabricated particles are Janus particles with different chemical properties on each hemisphere. The particles were also characterized by scanning and transmission electron microscopy for size and shape. The results showed aspherical particles with two hemispheres, confirming successful fabrication and chemical modification. Also, this work successfully demonstrated the synthesis, characterization and analysis of nanoscale Janus/amphiphilic particles nanoscale Janus particle.
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来源期刊
CiteScore
8.70
自引率
9.60%
发文量
2421
审稿时长
56 days
期刊介绍: Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.
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