用于盐酸多柔比星负载和扩散控制释放的纤维素纳米晶/唑基咪唑酸框架-L（CNC/ZIF-L）复合材料

IF 5.5 3区工程技术 Q1 ENGINEERING, CHEMICAL

Journal of the Taiwan Institute of Chemical Engineers Pub Date : 2024-11-15 DOI:10.1016/j.jtice.2024.105831

Christian J. Wijaya , Sandy B. Hartono , Jindrayani N. Putro , Juliana Anggono , Tarzan Sembiring , Herlian E. Putra , Maria Yuliana , Jenni Lie , Shella P. Santoso , Chien-Yen Chen , Felycia E. Soetaredjo , Suryadi Ismadji , Setiyo Gunawan

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引用次数: 0

摘要

背景沸石咪唑盐酸盐框架-L（ZIF-L）作为盐酸多柔比星（DOX）药物载体在口服化疗应用方面具有巨大潜力。这一医疗应用将极大地支持癌症治疗的发展并降低癌症死亡率。然而，作为一种金属有机框架（MOFs），ZIF-L 在生物医学应用中面临着一些挑战，这些挑战影响了药物的负载和释放机制。重要发现由于存在丰富的活性官能团，CNCs 的加入提高了 CNCs/ZIF-L 复合材料的 DOX 负载能力，达到 1508.91 ± 7.72 mg/g。此外，DOX 释放曲线是另一个有趣的潜力，它是通过扩散控制释放机制实现的。这表明 CNCs/ZIF-L 复合材料具有口服给药能力，可在一定浓度水平上持续释放 DOX，从而延长治疗时间。此外，DOX@CNCs/ZIF-L 药物的 IC50 值达到 480.21 mg/L，这证明即使以固体材料的形式口服 DOX，其药效仍能保持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cellulose nanocrystals/zeolitic imidazolate framework-L (CNCs/ZIF-L) composites for loading and diffusion-controlled release of doxorubicin hydrochloride

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Cellulose nanocrystals/zeolitic imidazolate framework-L (CNCs/ZIF-L) composites for loading and diffusion-controlled release of doxorubicin hydrochloride

Background

Zeolitic imidazolate framework-L (ZIF-L) has great potential as a doxorubicin hydrochloride (DOX) drug carrier for oral chemotherapy applications. This medical application will greatly support the development of cancer treatment and reduce the cancer fatality rate. However, ZIF-L as a type of metal-organic framework (MOFs) faces several challenges to be implemented in biomedical applications which impact the drug loading and release mechanisms.

Methods

CNCs/ZIF-L composites were fabricated via a green in-situ method using CNCs mass percentages of 2.5, 5, 7.5, and 10 % of Zn(NO₃)₂·6H₂O. All composites were tested for the DOX loading and release mechanisms and antioxidant activity.

Significant findings

Here, the addition of CNCs enhances the DOX loading capacity of CNCs/ZIF-L composite up to 1508.91 ± 7.72 mg/g due to the presence of abundant active functional groups. In addition, the DOX release profile is another interesting potential that occurs through a diffusion-controlled release mechanism. This shows the ability of CNCs/ZIF-L composite to deliver drugs orally where DOX is released consistently at a certain concentration level for prolonged treatment. Moreover, the IC₅₀ value of DOX@CNCs/ZIF-L drug reaching 480.21 mg/L proves that the effectiveness of DOX is maintained even though it is administered orally in the form of solid material.

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来源期刊

Journal of the Taiwan Institute of Chemical Engineers 工程技术-工程：化工

CiteScore

9.10

自引率

14.00%

发文量

362

审稿时长

35 days

期刊介绍： Journal of the Taiwan Institute of Chemical Engineers (formerly known as Journal of the Chinese Institute of Chemical Engineers) publishes original works, from fundamental principles to practical applications, in the broad field of chemical engineering with special focus on three aspects: Chemical and Biomolecular Science and Technology, Energy and Environmental Science and Technology, and Materials Science and Technology. Authors should choose for their manuscript an appropriate aspect section and a few related classifications when submitting to the journal online.