{"title":"糖尿病肾病患者的脂质代谢状况","authors":"Lola Daminova MD, PhD, DSc , Sitorakhon Muminova PhD , Bakhodir Nigmonov PhD","doi":"10.1016/j.aggp.2024.100095","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to evaluate the state of lipid metabolism in patients with diabetic nephropathy.</div></div><div><h3>Methods</h3><div>In this open label, randomised, prospective study. The study included 120 patients with type 2 diabetes, whose average age was 58.79 ± 1.27 years. In general, the average diabetes experience was 7 ± 3.16 years, HbA1C-9.3 ± 1.82 %, BMI-28.05 ± 3.45. Non-HDL cholesterol levels were calculated (non-HDL cholesterol = total cholesterol - HDL).</div></div><div><h3>Results</h3><div>As a result of the analysis, a negative relationship of moderate strength was revealed between eGFRcr levels in the blood of TCh (<em>r</em> = -0.32; <em>p</em> < 0.01), triglycerides (<em>r</em> = -0.51; <em>p</em> < 0.018), non-HDL (<em>r</em> = –0.44; <em>p</em> < 0.01) and weak positive association with HDL (<em>r</em> = 0.28; <em>p</em> = 0.01). Negative relationships were also established between the A/Cr index and the blood level of TCh (<em>r</em> = -0.37; <em>p</em> < 0.01), triglycerides (<em>r</em> = –0.42; <em>p</em> < 0.01), non-HDL (<em>r</em> = – 0.35; <em>p</em> < 0.01)/</div></div><div><h3>Conclusion</h3><div>Therefore, in patients with type 2 diabetes, it is advisable to determine the level of TG in the blood even with reference or slightly elevated levels of TG and non-HDL to predict DN.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100095"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The state of lipid metabolism in patients with diabetic nephropathy\",\"authors\":\"Lola Daminova MD, PhD, DSc , Sitorakhon Muminova PhD , Bakhodir Nigmonov PhD\",\"doi\":\"10.1016/j.aggp.2024.100095\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><div>This study aimed to evaluate the state of lipid metabolism in patients with diabetic nephropathy.</div></div><div><h3>Methods</h3><div>In this open label, randomised, prospective study. The study included 120 patients with type 2 diabetes, whose average age was 58.79 ± 1.27 years. In general, the average diabetes experience was 7 ± 3.16 years, HbA1C-9.3 ± 1.82 %, BMI-28.05 ± 3.45. Non-HDL cholesterol levels were calculated (non-HDL cholesterol = total cholesterol - HDL).</div></div><div><h3>Results</h3><div>As a result of the analysis, a negative relationship of moderate strength was revealed between eGFRcr levels in the blood of TCh (<em>r</em> = -0.32; <em>p</em> < 0.01), triglycerides (<em>r</em> = -0.51; <em>p</em> < 0.018), non-HDL (<em>r</em> = –0.44; <em>p</em> < 0.01) and weak positive association with HDL (<em>r</em> = 0.28; <em>p</em> = 0.01). Negative relationships were also established between the A/Cr index and the blood level of TCh (<em>r</em> = -0.37; <em>p</em> < 0.01), triglycerides (<em>r</em> = –0.42; <em>p</em> < 0.01), non-HDL (<em>r</em> = – 0.35; <em>p</em> < 0.01)/</div></div><div><h3>Conclusion</h3><div>Therefore, in patients with type 2 diabetes, it is advisable to determine the level of TG in the blood even with reference or slightly elevated levels of TG and non-HDL to predict DN.</div></div>\",\"PeriodicalId\":100119,\"journal\":{\"name\":\"Archives of Gerontology and Geriatrics Plus\",\"volume\":\"1 4\",\"pages\":\"Article 100095\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Gerontology and Geriatrics Plus\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950307824000924\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Gerontology and Geriatrics Plus","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950307824000924","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The state of lipid metabolism in patients with diabetic nephropathy
Aim
This study aimed to evaluate the state of lipid metabolism in patients with diabetic nephropathy.
Methods
In this open label, randomised, prospective study. The study included 120 patients with type 2 diabetes, whose average age was 58.79 ± 1.27 years. In general, the average diabetes experience was 7 ± 3.16 years, HbA1C-9.3 ± 1.82 %, BMI-28.05 ± 3.45. Non-HDL cholesterol levels were calculated (non-HDL cholesterol = total cholesterol - HDL).
Results
As a result of the analysis, a negative relationship of moderate strength was revealed between eGFRcr levels in the blood of TCh (r = -0.32; p < 0.01), triglycerides (r = -0.51; p < 0.018), non-HDL (r = –0.44; p < 0.01) and weak positive association with HDL (r = 0.28; p = 0.01). Negative relationships were also established between the A/Cr index and the blood level of TCh (r = -0.37; p < 0.01), triglycerides (r = –0.42; p < 0.01), non-HDL (r = – 0.35; p < 0.01)/
Conclusion
Therefore, in patients with type 2 diabetes, it is advisable to determine the level of TG in the blood even with reference or slightly elevated levels of TG and non-HDL to predict DN.
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