含有金银纳米颗粒的多反应形状记忆和自愈合水凝胶。

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Hüsna Kılıç and Deniz Ceylan
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引用次数: 0

摘要

在温度或光的刺激下,设计出了具有自愈和形状记忆特性的纳米复合智能凝胶(Nc-x),其中含有不同类型和尺寸的纳米粒子。Nc-x 网络是通过甲基丙烯酸硬脂酯(SM)和吡咯烷酮乙烯基(VP)在金和银纳米粒子存在下的批量聚合制备的。这种结构不含任何化学交联剂,通过疏水相互作用保持在一起,同时由 VP 单元的偶极-偶极键和 SM 侧链中的长烷基组成。得益于其结晶区域,形状记忆凝胶可以在存在长疏水链的情况下自我修复,此外,结构中的纳米颗粒(NPs)还有助于对亲水性和疏水性进行可控调节。Nc-x 凝胶具有自我修复能力,可独立或在刺激下修复机械损伤,并可从临时形态转变为永久形态。对人类皮肤成纤维细胞进行的体外实验表明,48 小时后细胞的存活率超过 100%,而且在 48 小时后进行的划痕实验中观察到细胞几乎完全恢复。根据所获得的结果,Nc-x 凝胶已被证明有潜力用作非侵入性伤口敷料材料,替代传统的伤口闭合方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multi-responsive shape memory and self-healing hydrogels with gold and silver nanoparticles†

Multi-responsive shape memory and self-healing hydrogels with gold and silver nanoparticles†

Nanocomposite smart gels (Nc-x) with self-healing and shape memory properties were designed in different types and size nano particles with temperature or light stimuli. Nc-x networks were prepared by bulk polymerization of stearyl methacrylate (SM) and vinyl pyrrolidone (VP) in the presence of gold and silver nanoparticles. The structure, which does not contain any chemical cross-linkers, is held together by hydrophobic interactions while consisting of dipole–dipole bonds of the VP units and long alkyl groups in the side chains of the SM. Thanks to their crystalline regions, shape memory gels can self-heal with the presence of long hydrophobic chains, and furthermore, the nanoparticles (NPs) incorporated into the structure facilitate the controlled tuning of hydrophilic and hydrophobic properties. Nc-x gels have the ability to self-heal by repairing mechanical damage independently or in the presence of a stimulus, as well as transforming from a temporary form to a permanent form. In vitro experiments on human skin fibroblast cells revealed that cell viability was over 100% after 48 hours and almost complete recovery was observed in scratch experiments at the end of this period. Based on the results obtained, Nc-x gels have been shown to have the potential to be used as a non-invasive wound dressing material alternative to traditional wound closure methods.

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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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