在美国中南部检测到类似于弓形虫的病原体。

IF 3.1 2区 医学 Q2 INFECTIOUS DISEASES
Rachel C Smith, Sarah Myers, Kellee D Sundstrom, Ragan Wilson, Ruth C Scimeca, Lindsay A Starkey, Susan E Little
{"title":"在美国中南部检测到类似于弓形虫的病原体。","authors":"Rachel C Smith,&nbsp;Sarah Myers,&nbsp;Kellee D Sundstrom,&nbsp;Ragan Wilson,&nbsp;Ruth C Scimeca,&nbsp;Lindsay A Starkey,&nbsp;Susan E Little","doi":"10.1016/j.ttbdis.2024.102411","DOIUrl":null,"url":null,"abstract":"<div><div><em>Anaplasma bovis</em> is primarily an infectious agent of ruminants, and has most commonly been reported in Asia, the Middle East, and Africa. Although the primary cause of human anaplasmosis is <em>Anaplasma phagocytophilum</em>, humans may rarely be infected by other <em>Anaplasma</em> spp. Human disease attributed to <em>A. bovis</em> has been occasionally reported, including an <em>A. bovis</em>-like agent in the United States. DNA of an <em>A. bovis</em>-like agent has been amplified from humans and the tick <em>Dermacentor variabilis</em> in the central region of the U.S., but larger prevalence studies among potential vectors or reservoir hosts in the U.S. have not been reported. The aim of this study was to evaluate the prevalence of <em>A. bovis</em>-like agent among <em>D. variabilis</em> and cattle in the Southcentral U.S. Previously extracted DNA from adult <em>D. variabilis</em> collected from Oklahoma (<em>n</em> = 38) and Kansas (<em>n</em> = 93), and blood of cattle from Oklahoma (<em>n</em> = 140) were tested by conventional PCR. Overall prevalence of <em>A. bovis</em>-like DNA within ticks was determined to be 3.1% (4/131), and all positive ticks originated from Oklahoma. Overall prevalence in bovine blood was determined to be 0% (0/140). These findings confirm the presence of an <em>A. bovis</em>-like agent, a potentially zoonotic pathogen, among ticks in the Southcentral U.S.; this agent is likely underrecognized and has been detected in parts of the U.S. that lie outside of the established geographic range for <em>A. phagocytophilum</em>. Further investigation and surveillance are necessary to elucidate possible reservoirs of <em>A. bovis</em> in the U.S., further evaluate the burden of human infection, and fully characterize genetic differences between the <em>A. bovis</em>-like agent detected in the U.S. and <em>A. bovis</em> in other regions of the world.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"15 6","pages":"Article 102411"},"PeriodicalIF":3.1000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Detection of Anaplasma bovis-like agent in the Southcentral United States\",\"authors\":\"Rachel C Smith,&nbsp;Sarah Myers,&nbsp;Kellee D Sundstrom,&nbsp;Ragan Wilson,&nbsp;Ruth C Scimeca,&nbsp;Lindsay A Starkey,&nbsp;Susan E Little\",\"doi\":\"10.1016/j.ttbdis.2024.102411\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div><em>Anaplasma bovis</em> is primarily an infectious agent of ruminants, and has most commonly been reported in Asia, the Middle East, and Africa. Although the primary cause of human anaplasmosis is <em>Anaplasma phagocytophilum</em>, humans may rarely be infected by other <em>Anaplasma</em> spp. Human disease attributed to <em>A. bovis</em> has been occasionally reported, including an <em>A. bovis</em>-like agent in the United States. DNA of an <em>A. bovis</em>-like agent has been amplified from humans and the tick <em>Dermacentor variabilis</em> in the central region of the U.S., but larger prevalence studies among potential vectors or reservoir hosts in the U.S. have not been reported. The aim of this study was to evaluate the prevalence of <em>A. bovis</em>-like agent among <em>D. variabilis</em> and cattle in the Southcentral U.S. Previously extracted DNA from adult <em>D. variabilis</em> collected from Oklahoma (<em>n</em> = 38) and Kansas (<em>n</em> = 93), and blood of cattle from Oklahoma (<em>n</em> = 140) were tested by conventional PCR. Overall prevalence of <em>A. bovis</em>-like DNA within ticks was determined to be 3.1% (4/131), and all positive ticks originated from Oklahoma. Overall prevalence in bovine blood was determined to be 0% (0/140). These findings confirm the presence of an <em>A. bovis</em>-like agent, a potentially zoonotic pathogen, among ticks in the Southcentral U.S.; this agent is likely underrecognized and has been detected in parts of the U.S. that lie outside of the established geographic range for <em>A. phagocytophilum</em>. Further investigation and surveillance are necessary to elucidate possible reservoirs of <em>A. bovis</em> in the U.S., further evaluate the burden of human infection, and fully characterize genetic differences between the <em>A. bovis</em>-like agent detected in the U.S. and <em>A. bovis</em> in other regions of the world.</div></div>\",\"PeriodicalId\":49320,\"journal\":{\"name\":\"Ticks and Tick-borne Diseases\",\"volume\":\"15 6\",\"pages\":\"Article 102411\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ticks and Tick-borne Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1877959X24001043\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ticks and Tick-borne Diseases","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877959X24001043","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

弓形虫主要是反刍动物的传染源,最常见于亚洲、中东和非洲。虽然人类无形体病的主要病原体是噬细胞嗜血无形体,但人类也可能极少受到其他无形体属的感染,偶尔也有因牛无形体引起人类疾病的报道,其中包括美国的牛无形体样病原体。在美国中部地区,已从人类和蜱虫 Dermacentor variabilis 中扩增出了牛海绵状疟原虫样病原体的 DNA,但在美国的潜在传播媒介或贮存宿主中进行的更大规模的流行研究尚未见报道。本研究的目的是评估美国中南部变种蜱和牛中牛海绵状疟原虫样病原体的流行情况。先前从俄克拉荷马州(n = 38)和堪萨斯州(n = 93)采集的变种蜱成虫中提取的 DNA 和俄克拉荷马州的牛(n = 140)的血液都通过常规 PCR 进行了检测。经测定,蜱体内类牛蜱 DNA 的总体流行率为 3.1%(4/131),所有阳性蜱均来自俄克拉荷马州。牛血中的总体流行率为 0%(0/140)。这些发现证实了美国中南部地区的蜱虫中存在一种类似牛蜱的病原体,这是一种潜在的人畜共患病原体;这种病原体很可能未被充分认识到,而且在美国的一些地区也检测到了这种病原体,而这些地区并不在噬菌体的既定地理范围内。有必要开展进一步的调查和监测,以查明美国可能存在的噬菌体贮存库,进一步评估人类感染的负担,并充分描述在美国检测到的噬菌体样病原体与世界其他地区的噬菌体之间的遗传差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Detection of Anaplasma bovis-like agent in the Southcentral United States
Anaplasma bovis is primarily an infectious agent of ruminants, and has most commonly been reported in Asia, the Middle East, and Africa. Although the primary cause of human anaplasmosis is Anaplasma phagocytophilum, humans may rarely be infected by other Anaplasma spp. Human disease attributed to A. bovis has been occasionally reported, including an A. bovis-like agent in the United States. DNA of an A. bovis-like agent has been amplified from humans and the tick Dermacentor variabilis in the central region of the U.S., but larger prevalence studies among potential vectors or reservoir hosts in the U.S. have not been reported. The aim of this study was to evaluate the prevalence of A. bovis-like agent among D. variabilis and cattle in the Southcentral U.S. Previously extracted DNA from adult D. variabilis collected from Oklahoma (n = 38) and Kansas (n = 93), and blood of cattle from Oklahoma (n = 140) were tested by conventional PCR. Overall prevalence of A. bovis-like DNA within ticks was determined to be 3.1% (4/131), and all positive ticks originated from Oklahoma. Overall prevalence in bovine blood was determined to be 0% (0/140). These findings confirm the presence of an A. bovis-like agent, a potentially zoonotic pathogen, among ticks in the Southcentral U.S.; this agent is likely underrecognized and has been detected in parts of the U.S. that lie outside of the established geographic range for A. phagocytophilum. Further investigation and surveillance are necessary to elucidate possible reservoirs of A. bovis in the U.S., further evaluate the burden of human infection, and fully characterize genetic differences between the A. bovis-like agent detected in the U.S. and A. bovis in other regions of the world.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Ticks and Tick-borne Diseases
Ticks and Tick-borne Diseases INFECTIOUS DISEASES-MICROBIOLOGY
CiteScore
6.90
自引率
12.50%
发文量
185
审稿时长
6-12 weeks
期刊介绍: Ticks and Tick-borne Diseases is an international, peer-reviewed scientific journal. It publishes original research papers, short communications, state-of-the-art mini-reviews, letters to the editor, clinical-case studies, announcements of pertinent international meetings, and editorials. The journal covers a broad spectrum and brings together various disciplines, for example, zoology, microbiology, molecular biology, genetics, mathematical modelling, veterinary and human medicine. Multidisciplinary approaches and the use of conventional and novel methods/methodologies (in the field and in the laboratory) are crucial for deeper understanding of the natural processes and human behaviour/activities that result in human or animal diseases and in economic effects of ticks and tick-borne pathogens. Such understanding is essential for management of tick populations and tick-borne diseases in an effective and environmentally acceptable manner.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信