伽玛刀放射外科治疗脑干胶质瘤的临床疗效：机构经验。

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2024-11-01 DOI:10.12669/pjms.40.10.9658

Aurangzeb Kalhoro, Kashif Ahmed, Abdul Sattar M Hashim

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引用次数: 0

摘要

目的：过去，在巴基斯坦治疗脑干的方法是手术或放置分流器。目前，伽玛刀手术是脑深部病变手术的替代方案。在本研究中，我们展示了本中心使用伽玛刀手术治疗的临床经验：这是一项描述性研究，研究时间为 2016 年 2 月至 2021 年 10 月。卡拉奇神经脊髓和癌症护理研究所共选取了 47 名局灶性脑干胶质瘤患者进行伽玛刀放射外科手术：平均症状持续时间为 31.9 个月（SD10.5± 3 个月）。伽玛刀放射手术期间，24 名患者（51%）的 KPS 评分为 90，21 名患者（44.6%）的 KPS 评分为 80，2 名患者（4.2%）的 KPS 评分为 70。4名患者（10.6%）在伽玛刀放射外科手术前接受过常规放疗：结论：在各种胶质瘤中，其危险性不仅因类型而异，也因其在大脑中的复杂位置而异。伽玛刀放射治疗的疗效非常好，尤其是在治疗高级别肿瘤时，在成人和儿童病例中均表现出卓越的疗效。

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Gamma knife radiosurgery clinical efficacy for brain stem glioma: The institutional experience.

Objective: In the past, brain stem was treated with surgery or placement of shunt in Pakistan. Gamma Knife surgery is currently an alternative to surgery for deep brain lesions. In the current study, we show the clinical experience of our Centre treated with Gamma Knife surgery.

Methods: This is a descriptive study conducted between February 2016 and October 2021. We had total 47 patients presented with focal brainstem gliomas which were selected for Gamma knife radiosurgery at the Neurospinal and Cancer Care Institute Karachi.

Results: Clinical Response was observed among them 20 (42.55%) patients improved, 22(46.80%) were stable, while 05 (10.63%) got worse The mean duration of symptoms was 31.9(SD10.5± 3months). Karnofsky Performance Status (KPS) scores during Gamma knife radiosurgery were 90 in 24 patients (51%), 80 in 21 patients (44.6%), and 70 in two patients (4.2%). Four patients (10.6%) had received conventional radiotherapy before Gamma knife radiosurgery.

Conclusion: Among the diverse gliomas, their peril varies not just by type but also by their intricate location within the brain. The efficacy of gamma knife radiation is excellent particularly when tackling high-grade tumors, exhibiting its prowess in both adult and pediatric cases.

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.