来自乌达加瓦埃曲霉的两种新的喹唑啉酮生物碱。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-11-18 DOI:10.1080/10286020.2024.2424910

Lin Liang, Xi Yuan, Xiao-Ya Xian, Xian-Li Zhou, Tong-Dong Kuang, Jin-Tao Gao, Li-Sheng Wang, Cheng-Qin Liang

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引用次数: 0

摘要

从桂林会仙湿地的湿地土源真菌乌达曲霉（Aspergillus udagawae）的培养物中分离出了两种新的喹唑啉酮生物碱--苯并马来文F（1）和喹唑啉C（2），以及四种已知的喹唑啉酮（3-6）。通过详细的光谱分析，包括一维、二维核磁共振、质谱和红外光谱，阐明了它们的结构。此外，抗炎结果表明，与阳性对照吲哚美辛（IC50 = 31.6 ± 0.4 μM）相比，化合物 1、2、4 和 5 对脂多糖（LPS）激活的 RAW264.7 细胞的 NO 生成具有显著的抑制作用，IC50 值分别为 24.5 ± 0.1、29.7 ± 0.1、29.4 ± 0.1 和 31.0 ± 0.1 μM。

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Two new quinazolinone alkaloids from Aspergillus udagawae.

Two new quinazolinone alkaloids, benzomalvin F (1), and quinadoline C (2), along with four known quinazolinones (3-6), were isolated from cultures of the wetland-soil-derived fungus Aspergillus udagawae from the Huixian wetland in Guilin. Their structures were elucidated based on detailed spectroscopic analysis, including 1D, 2D NMR, mass spectrometry, and IR spectra. In addition, the anti-inflammatory results showed that compounds 1, 2, 4, and 5 had significant inhibitory effects on NO production in RAW264.7 cells activated by lipopolysaccharide (LPS), with IC₅₀ values of 24.5 ± 0.1, 29.7 ± 0.1, 29.4 ± 0.1, and 31.0 ± 0.1 µM respectively, compared with the positive control indomethacin (IC₅₀ = 31.6 ± 0.4 μM).

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.