通过氧化应激途径治疗黑色素瘤的多功能低温光热纳米药物

IF 6.6 2区 医学 Q1 NANOSCIENCE & NANOTECHNOLOGY
International Journal of Nanomedicine Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S487683
Dou Zhang, Xuyi Liu, Xiong Li, Xinyi Cai, Zhenying Diao, Long Qiu, Xuelin Chen, Yuyu Liu, Jianbo Sun, Daxiang Cui, Qiaoyuan Ye, Ting Yin
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引用次数: 0

摘要

目的:黑色素瘤是一种侵袭性极强、危害极大的恶性皮肤肿瘤,因此迫切需要开发针对黑色素瘤的有效治疗方法。本研究的主要目的是构建一种多功能纳米药物(GNR@PEG-Qu),从氧化应激途径研究其对黑色素瘤的治疗效果:首先,合成并表征了纳米药物 GNR@PEG-Qu,证实了其光热和抗氧化特性。此外,还观察了其体内成像能力。最后,观察了 GNR@PEG-Qu 在体内和体外的肿瘤抑制作用及其生物安全性:结果:GNR@PEG-Qu 具有良好的光热和抗氧化特性。结果:GNR@PEG-Qu 具有良好的光热和抗氧化特性,在第二近红外窗口(NIR-II)1064 nm 激光照射下,GNR@PEG-Qu 通过低温光热疗法(PTT)辅助药物化疗显示出抗肿瘤能力。GNR@PEG-Qu 能充分利用槲皮素的抗氧化能力,降低黑色素瘤的 ROS 水平,缓解氧化应激状态,实现肿瘤部位的 "氧化应激规避"。槲皮素还能下调热休克蛋白Hsp70的表达,从而改善肿瘤部位的热敏感性,提高低温PTT的疗效:GNR@PEG-Qu纳米试剂具有协同治疗和较高的抑瘤效果,是利用槲皮素(Qu)包覆金纳米棒(GNR@PEG)实现避免氧化应激和协同治疗黑色素瘤的一种很有前景的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Multifunctional Low-Temperature Photothermal Nanomedicine for Melanoma Treatment via the Oxidative Stress Pathway Therapy.

Purpose: Melanoma is a highly aggressive and dangerous malignant skin tumor and there is an urgent need to develop effective therapeutic approaches against melanoma. The main objective of this study was to construct a multifunctional nanomedicine (GNR@PEG-Qu) to investigate its therapeutic effect on melanoma from the oxidative stress pathway.

Methods: First, the nanomedicine GNR@PEG-Qu was synthesized and characterized, and its photothermal and antioxidant properties were confirmed. In addition, in vivo imaging capabilities were observed. Finally, the tumor inhibitory effects of GNR@PEG-Qu in vivo and in vitro as well as its biosafety were observed.

Results: GNR@PEG-Qu shows good photothermal and anti-oxidation properties. Following exposure to 1064 nm laser irradiation in the second near-infrared II (NIR-II) window, GNR@PEG-Qu shows anti-tumor ability through low-temperature photothermal therapy (PTT) adjuvant drug chemotherapy. GNR@PEG-Qu makes full use of the antioxidant capacity of quercetin, reduces ROS levels in melanoma, alleviates oxidative stress state, and achieves "oxidative stress avoidance" at the tumor site. Quercetin can also downregulate the expression of the heat shock protein Hsp70, which will improve the thermal sensitivity of the tumor site and enhance the efficacy of low-temperature PTT.

Conclusion: GNR@PEG-Qu nanoagent exhibits synergistic treatment and high tumor inhibition effects, which is a promising strategy developed to achieve oxidative stress avoidance and synergistic therapy of melanoma using quercetin (Qu)-coated gold nanorod (GNR@PEG).

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来源期刊
International Journal of Nanomedicine
International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY
CiteScore
14.40
自引率
3.80%
发文量
511
审稿时长
1.4 months
期刊介绍: The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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