抗免疫球蛋白 E 抗体的生物效应和临床应用

IF 2.5 4区医学 Q3 ALLERGY

International Archives of Allergy and Immunology Pub Date : 2024-11-16 DOI:10.1159/000542428

Fan Zhang, Yuan Qian, Jiashun Liao, Chuang Zhou, Wei Ren, Qiuzi Jin

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引用次数: 0

摘要

免疫球蛋白 E（IgE）在过敏性疾病的发生和发展中起着至关重要的作用。自 1967 年发现 IgE 以来，过敏性炎症性疾病的发病机制逐渐被揭示，从而为抗 IgE 治疗性抗体的开发提供了理论基础，抗 IgE 抗体也成为治疗过敏性疾病的新方法。本文旨在通过研究全球相关文献，特别是近五年来有关奥马珠单抗的文献，总结和阐述抗 IgE 抗体的生物效应机制和临床应用。我们力求为抗过敏治疗新策略的形成奠定理论基础。

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Biological Effects and Clinical Application of the Anti-Immunoglobulin E Antibody.

Immunoglobulin E (IgE) plays a crucial role in the occurrence and development of allergic diseases. Since the discovery of IgE in 1967, the pathogenesis of allergic inflammatory diseases has been progressively revealed thereby providing a theoretical foundation for the development of therapeutic anti-IgE antibodies, which have emerged as a new method for the treatment of allergic diseases. In this paper, we aim to summarize and elaborate on the mechanism of biological effects and clinical application of anti-IgE antibodies by examining related global literature, particularly regarding Omalizumab in the past 5 years. We seek to establish theoretical foundations for the formation of new strategies for anti-allergic treatment.

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来源期刊

International Archives of Allergy and Immunology 医学-过敏

CiteScore

5.60

自引率

3.60%

发文量

105

审稿时长

2 months

期刊介绍： ''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.