血管紧张素转换酶基因 I/D 多态性与银屑病（包括合并高血压和糖尿病的银屑病）的关系

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S482663

Jiayun Liu, Rui Sun, Guomin Gao, Mogen Zhang, Huiping Fan, Xiaonan Ma, Yanhong Yu, Yanmei Yuan, Lulu Zhang, Changying Niu

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引用次数: 0

摘要

目的：血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与银屑病之间的关系尚不清楚。本研究旨在分析中国汉族人群中血管紧张素转换酶基因 I/D 多态性与寻常型银屑病发病风险之间的关系，并探讨血管紧张素转换酶基因 I/D 多态性与银屑病合并高血压和糖尿病之间的相关性：方法：从中国汉族人群中选取了 358 名寻常型银屑病患者和 347 名年龄和性别匹配的健康志愿者。收集了患者的临床数据，包括血压和空腹血糖。聚合酶链式反应（PCR）分析了 ACE 基因 I/D 多态性。用皮尔逊χ²检验分析了ACE基因I/D多态性与寻常型银屑病、合并高血压和糖尿病之间的关系：与对照组相比，银屑病患者中 ACE II 基因型（OR = 1.84，95% CI = 1.30，2.61；P < 0.01）和 I 等位基因（OR = 1.51，95% CI = 1.22，1.86；P < 0.01）的频率明显较高。相反，与对照组相比，银屑病患者中 ACE DD 基因型（OR = 0.62，95% CI = 0.44，0.87；P <0.01）和 D 等位基因（OR = 0.66，95% CI = 0.54，0.82；P <0.01）的频率明显较低。按血压和血糖异常分层后，未观察到有统计学意义的差异（P > 0.05）：结论：在中国北方汉族人群中，ACE II 基因型和 I 等位基因是寻常型银屑病的危险因素。

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The Relationship Between Angiotensin-Converting Enzyme Gene I/D Polymorphism and Psoriasis, Including Psoriasis with Comorbid Hypertension and Diabetes.

Objective: The relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and psoriasis remains unclear. This study aims to analyze the association between ACE gene I/D polymorphism and the risk of psoriasis vulgaris in the Chinese Han population and to examine the correlation between ACE gene I/D polymorphism and psoriasis with comorbid hypertension and diabetes.

Methods: A total of 358 patients with psoriasis vulgaris and 347 age- and sex-matched healthy volunteers from the Chinese Han population were selected. Clinical data, including blood pressure and fasting blood glucose, were collected from the patients. The ACE gene I/D polymorphism was analyzed using polymerase chain reaction (PCR). The association between ACE gene I/D polymorphism and psoriasis vulgaris, as well as comorbid hypertension and diabetes, was analyzed using the Pearson χ²-test.

Results: The frequency of the ACE II genotype (OR = 1.84, 95% CI = 1.30, 2.61; P < 0.01) and the I allele (OR = 1.51, 95% CI = 1.22, 1.86; P < 0.01) was significantly higher in psoriasis patients compared to the control group. Conversely, the frequency of the ACE DD genotype (OR = 0.62, 95% CI = 0.44, 0.87; P < 0.01) and the D allele (OR = 0.66, 95% CI = 0.54, 0.82; P < 0.01) was significantly lower in psoriasis patients compared to the control group. No statistically significant differences were observed when stratified by blood pressure and blood glucose abnormalities (P > 0.05).

Conclusion: The ACE II genotype and I allele are risk factors for psoriasis vulgaris in the Northern Chinese Han population.

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.