不同化疗方法对乳腺癌患者血脂水平的影响分析

IF 3.3 4区 医学 Q2 ONCOLOGY
Breast Cancer : Targets and Therapy Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI:10.2147/BCTT.S456422
Jiaqi Mu, Mai Zhou, GangJun Jiao
{"title":"不同化疗方法对乳腺癌患者血脂水平的影响分析","authors":"Jiaqi Mu, Mai Zhou, GangJun Jiao","doi":"10.2147/BCTT.S456422","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the impacts of distinct chemotherapy methods on blood lipid levels in breast cancer patients.</p><p><strong>Methods: </strong>Three hundred breast cancer patients were selected as the research subjects. The inclusion time limit was from January 2021 to January 2023, and all received treatment in our hospital. Based on the therapy plan, the patients were divided into group A (epirubicin + cyclophosphamide followed by paclitaxel regimen, 103 premenopausal cases + 61 postmenopausal cases), group B (docetaxel + cyclophosphamide regimen, 41 premenopausal instances + 37 postmenopausal instances), group C (docetaxel + carboplatin regimen, 61 premenopausal instances + 24 postmenopausal instances), comparing the changes in blood lipid levels of patients in each group at pre-therapy and post-therapy, and the abnormality frequency of blood lipids in every group of patients after therapy.</p><p><strong>Results: </strong>After treatment, the triglyceride (TG) levels of the three groups of patients were clearly greater than those at pre-therapy, and the high-density lipoprotein cholesterol (HDL-C) levels were clearly less than before therapy. The levels of low-density lipoprotein cholesterol (LDL-C) in group B and C patients were clearly greater than those before therapy in the same one, while the LDL-C levels in group A were clearly less than those before therapy in the same one; after therapy, the TG levels of patients in group A were clearly less than those in group B, and LDL-C, total Cholesterol (TC) levels were clearly less than that in group B and C (<i>P</i> < 0.05). The proportion of dyslipidemia in patients in the group A after therapy was clearly less than in group B (<i>P</i> < 0.05). After treatment, the HDL-C levels of premenopausal patients in the three groups were clearly less than those at pre-therapy. The TG, TC, and LDL-C levels of premenopausal patients in groups B and C were clearly greater than those at pre-therapy. The TG levels of premenopausal patients in group A were clearly less than those before therapy. After treatment, the TG and TC levels of premenopausal patients in group A were clearly less than those in group C, and the LDL-C levels were clearly less than those in group B and C (<i>P</i> < 0.05). The proportion of dyslipidemia in premenopausal patients in the group A and C after therapy was clearly less than the group B (<i>P</i> < 0.05). After therapy, the TG levels of postmenopausal patients in the three groups were clearly greater than those at pre-therapy, and the HDL-C levels were clearly less than those at pre-therapy. The LDL-C levels of postmenopausal patients in group B and C were clearly greater than those at pre-therapy. The TC and LDL-C levels of postmenopausal patients in group A were clearly less than those at pre-therapy; after therapy, the LDL-C and TC levels of postmenopausal patients in group A were clearly less than those in group B and C (<i>P</i> < 0.05). It had no statistically clear distinction in dyslipidemia among the three groups of postmenopausal patients after therapy (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Chemotherapy has adverse effects on the blood lipid levels of premenopausal and postmenopausal breast carcinoma patients and increases the incidence of dyslipidemia. Compared with other regimens, epirubicin+cyclophosphamide sequential paclitaxel regimen has little impact on blood lipid level of breast carcinoma.</p>","PeriodicalId":9106,"journal":{"name":"Breast Cancer : Targets and Therapy","volume":"16 ","pages":"745-760"},"PeriodicalIF":3.3000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566600/pdf/","citationCount":"0","resultStr":"{\"title\":\"Analysis of the Effects of Different Chemotherapy Methods on Blood Lipid Levels in Breast Cancer Patients.\",\"authors\":\"Jiaqi Mu, Mai Zhou, GangJun Jiao\",\"doi\":\"10.2147/BCTT.S456422\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To analyze the impacts of distinct chemotherapy methods on blood lipid levels in breast cancer patients.</p><p><strong>Methods: </strong>Three hundred breast cancer patients were selected as the research subjects. The inclusion time limit was from January 2021 to January 2023, and all received treatment in our hospital. Based on the therapy plan, the patients were divided into group A (epirubicin + cyclophosphamide followed by paclitaxel regimen, 103 premenopausal cases + 61 postmenopausal cases), group B (docetaxel + cyclophosphamide regimen, 41 premenopausal instances + 37 postmenopausal instances), group C (docetaxel + carboplatin regimen, 61 premenopausal instances + 24 postmenopausal instances), comparing the changes in blood lipid levels of patients in each group at pre-therapy and post-therapy, and the abnormality frequency of blood lipids in every group of patients after therapy.</p><p><strong>Results: </strong>After treatment, the triglyceride (TG) levels of the three groups of patients were clearly greater than those at pre-therapy, and the high-density lipoprotein cholesterol (HDL-C) levels were clearly less than before therapy. The levels of low-density lipoprotein cholesterol (LDL-C) in group B and C patients were clearly greater than those before therapy in the same one, while the LDL-C levels in group A were clearly less than those before therapy in the same one; after therapy, the TG levels of patients in group A were clearly less than those in group B, and LDL-C, total Cholesterol (TC) levels were clearly less than that in group B and C (<i>P</i> < 0.05). The proportion of dyslipidemia in patients in the group A after therapy was clearly less than in group B (<i>P</i> < 0.05). After treatment, the HDL-C levels of premenopausal patients in the three groups were clearly less than those at pre-therapy. The TG, TC, and LDL-C levels of premenopausal patients in groups B and C were clearly greater than those at pre-therapy. The TG levels of premenopausal patients in group A were clearly less than those before therapy. After treatment, the TG and TC levels of premenopausal patients in group A were clearly less than those in group C, and the LDL-C levels were clearly less than those in group B and C (<i>P</i> < 0.05). The proportion of dyslipidemia in premenopausal patients in the group A and C after therapy was clearly less than the group B (<i>P</i> < 0.05). After therapy, the TG levels of postmenopausal patients in the three groups were clearly greater than those at pre-therapy, and the HDL-C levels were clearly less than those at pre-therapy. The LDL-C levels of postmenopausal patients in group B and C were clearly greater than those at pre-therapy. The TC and LDL-C levels of postmenopausal patients in group A were clearly less than those at pre-therapy; after therapy, the LDL-C and TC levels of postmenopausal patients in group A were clearly less than those in group B and C (<i>P</i> < 0.05). It had no statistically clear distinction in dyslipidemia among the three groups of postmenopausal patients after therapy (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Chemotherapy has adverse effects on the blood lipid levels of premenopausal and postmenopausal breast carcinoma patients and increases the incidence of dyslipidemia. Compared with other regimens, epirubicin+cyclophosphamide sequential paclitaxel regimen has little impact on blood lipid level of breast carcinoma.</p>\",\"PeriodicalId\":9106,\"journal\":{\"name\":\"Breast Cancer : Targets and Therapy\",\"volume\":\"16 \",\"pages\":\"745-760\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-11-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566600/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Breast Cancer : Targets and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/BCTT.S456422\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Breast Cancer : Targets and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/BCTT.S456422","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:分析不同化疗方法对乳腺癌患者血脂水平的影响:选取 300 名乳腺癌患者作为研究对象。纳入时限为 2021 年 1 月至 2023 年 1 月,所有患者均在我院接受治疗。根据治疗方案,将患者分为A组(表柔比星+环磷酰胺后紫杉醇方案,绝经前103例+绝经后61例)、B组(多西他赛+环磷酰胺方案,绝经前41例+绝经后37例)和C组(多西他赛+环磷酰胺方案,绝经前41例+绝经后37例)、C组(多西他赛+卡铂方案,绝经前61例+绝经后24例),比较各组患者治疗前和治疗后的血脂水平变化,以及治疗后各组患者的血脂异常频率。结果显示治疗后,三组患者的甘油三酯(TG)水平明显高于治疗前,高密度脂蛋白胆固醇(HDL-C)水平明显低于治疗前。B组和C组患者的低密度脂蛋白胆固醇(LDL-C)水平明显高于治疗前的同一位,而A组患者的低密度脂蛋白胆固醇(LDL-C)水平明显低于治疗前的同一位;治疗后,A组患者的TG水平明显低于B组,低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)水平明显低于B组和C组(P<0.05)。治疗后,A 组患者血脂异常的比例明显低于 B 组(P < 0.05)。治疗后,三组绝经前患者的 HDL-C 水平均明显低于治疗前。B 组和 C 组绝经前患者的 TG、TC 和 LDL-C 水平明显高于治疗前。A 组绝经前患者的 TG 水平明显低于治疗前。治疗后,A 组绝经前患者的 TG 和 TC 水平明显低于 C 组,LDL-C 水平明显低于 B 组和 C 组(P < 0.05)。治疗后,A 组和 C 组绝经前患者血脂异常的比例明显低于 B 组(P<0.05)。治疗后,三组绝经后患者的 TG 水平明显高于治疗前,HDL-C 水平明显低于治疗前。B 组和 C 组绝经后患者的 LDL-C 水平明显高于治疗前。A 组绝经后患者的 TC 和 LDL-C 水平明显低于治疗前;治疗后,A 组绝经后患者的 LDL-C 和 TC 水平明显低于 B 组和 C 组(P < 0.05)。三组绝经后患者治疗后血脂异常的差异无统计学意义(P>0.05):结论:化疗对绝经前和绝经后乳腺癌患者的血脂水平有不良影响,会增加血脂异常的发生率。与其他方案相比,表柔比星+环磷酰胺序贯紫杉醇方案对乳腺癌患者的血脂影响较小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of the Effects of Different Chemotherapy Methods on Blood Lipid Levels in Breast Cancer Patients.

Purpose: To analyze the impacts of distinct chemotherapy methods on blood lipid levels in breast cancer patients.

Methods: Three hundred breast cancer patients were selected as the research subjects. The inclusion time limit was from January 2021 to January 2023, and all received treatment in our hospital. Based on the therapy plan, the patients were divided into group A (epirubicin + cyclophosphamide followed by paclitaxel regimen, 103 premenopausal cases + 61 postmenopausal cases), group B (docetaxel + cyclophosphamide regimen, 41 premenopausal instances + 37 postmenopausal instances), group C (docetaxel + carboplatin regimen, 61 premenopausal instances + 24 postmenopausal instances), comparing the changes in blood lipid levels of patients in each group at pre-therapy and post-therapy, and the abnormality frequency of blood lipids in every group of patients after therapy.

Results: After treatment, the triglyceride (TG) levels of the three groups of patients were clearly greater than those at pre-therapy, and the high-density lipoprotein cholesterol (HDL-C) levels were clearly less than before therapy. The levels of low-density lipoprotein cholesterol (LDL-C) in group B and C patients were clearly greater than those before therapy in the same one, while the LDL-C levels in group A were clearly less than those before therapy in the same one; after therapy, the TG levels of patients in group A were clearly less than those in group B, and LDL-C, total Cholesterol (TC) levels were clearly less than that in group B and C (P < 0.05). The proportion of dyslipidemia in patients in the group A after therapy was clearly less than in group B (P < 0.05). After treatment, the HDL-C levels of premenopausal patients in the three groups were clearly less than those at pre-therapy. The TG, TC, and LDL-C levels of premenopausal patients in groups B and C were clearly greater than those at pre-therapy. The TG levels of premenopausal patients in group A were clearly less than those before therapy. After treatment, the TG and TC levels of premenopausal patients in group A were clearly less than those in group C, and the LDL-C levels were clearly less than those in group B and C (P < 0.05). The proportion of dyslipidemia in premenopausal patients in the group A and C after therapy was clearly less than the group B (P < 0.05). After therapy, the TG levels of postmenopausal patients in the three groups were clearly greater than those at pre-therapy, and the HDL-C levels were clearly less than those at pre-therapy. The LDL-C levels of postmenopausal patients in group B and C were clearly greater than those at pre-therapy. The TC and LDL-C levels of postmenopausal patients in group A were clearly less than those at pre-therapy; after therapy, the LDL-C and TC levels of postmenopausal patients in group A were clearly less than those in group B and C (P < 0.05). It had no statistically clear distinction in dyslipidemia among the three groups of postmenopausal patients after therapy (P > 0.05).

Conclusion: Chemotherapy has adverse effects on the blood lipid levels of premenopausal and postmenopausal breast carcinoma patients and increases the incidence of dyslipidemia. Compared with other regimens, epirubicin+cyclophosphamide sequential paclitaxel regimen has little impact on blood lipid level of breast carcinoma.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.10
自引率
0.00%
发文量
40
审稿时长
16 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信