{"title":"用 40 赫兹白光发光二极管缓解链脲佐菌素在体内诱发的精神症状","authors":"Elham Soleimani, Abolhassan Ahmadiani, Maryam Bazrgar, Fariba Khodagholi, Afsaneh Eliassi","doi":"10.32598/bcn.2024.1856.1","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>A 40-Hz white light emitting diode (WLED) has emerged as an alternative nonpharmacological and noninvasive approach to Alzheimer disease (AD). Here, we investigated the therapeutic effects of 40-Hz WLED on psychiatric symptoms (PS) and the contribution of mitochondrial factors in the early stages of sporadic AD (sAD) in rats.</p><p><strong>Methods: </strong>In male Wistar rats, the AD model was induced via intracerebroventricular (ICV) injection of streptozotocin (STZ). After recovering (7 days) from stereotaxic surgery, 40-Hz WLED exposure was performed for 7 consecutive days lasting 15 min/d. Behavioral (elevated plus maze (EPM), force swim test, and social interaction test), enzymatic, and molecular assays were conducted 24 hours after the last 40-Hz WLED exposure.</p><p><strong>Results: </strong>Behavioral tasks revealed that 40-Hz WLED exposure in STZ-induced toxicity rats lowered anxiety and depression and increased social interaction. Furthermore, the 40-Hz WLED therapy in STZ-induced toxicity rats increased catalase (CAT) activity in the amygdala, decreased the activity of monoamine oxidases A and B in the whole brain, and increased mitochondrial DNA in the hippocampus.</p><p><strong>Conclusion: </strong>The current study supports that 40-Hz WLED therapy improved PS and biomarkers in the early stages of sAD. Also, a potential relationship between PS and alterations in mitochondrial markers in certain brain regions seems to exist.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 4","pages":"463-476"},"PeriodicalIF":1.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565670/pdf/","citationCount":"0","resultStr":"{\"title\":\"The 40-Hz White Light Emitting Diode to Alleviate Psychiatric Symptoms Induced by Streptozotocin In Vivo.\",\"authors\":\"Elham Soleimani, Abolhassan Ahmadiani, Maryam Bazrgar, Fariba Khodagholi, Afsaneh Eliassi\",\"doi\":\"10.32598/bcn.2024.1856.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>A 40-Hz white light emitting diode (WLED) has emerged as an alternative nonpharmacological and noninvasive approach to Alzheimer disease (AD). 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引用次数: 0
摘要
简介：40赫兹白光发光二极管（WLED）已成为治疗阿尔茨海默病（AD）的另一种非药物和非侵入性方法。在此，我们研究了 40 赫兹白光发光二极管对大鼠精神症状（PS）的治疗效果，以及线粒体因素在散发性阿兹海默症（sAD）早期阶段的作用：方法：雄性Wistar大鼠通过脑室内注射链脲佐菌素（STZ）诱导AD模型。从立体定向手术中恢复（7 天）后，连续 7 天暴露于 40Hz WLED，持续 15 分钟/天。在最后一次40赫兹WLED照射24小时后进行行为（高架加迷宫（EPM）、用力游泳试验和社会互动试验）、酶和分子检测：结果：行为任务显示，STZ 诱导的毒性大鼠暴露于 40Hz WLED 可降低焦虑和抑郁程度，增加社会互动。此外，对 STZ 诱导的毒性大鼠进行 40Hz WLED 治疗可提高杏仁核中过氧化氢酶（CAT）的活性，降低全脑中单胺氧化酶 A 和 B 的活性，并提高海马中线粒体 DNA 的活性：目前的研究证实，40 Hz WLED疗法改善了sAD早期阶段的PS和生物标志物。此外，PS 与某些脑区线粒体标志物的改变之间似乎存在潜在关系。
The 40-Hz White Light Emitting Diode to Alleviate Psychiatric Symptoms Induced by Streptozotocin In Vivo.
Introduction: A 40-Hz white light emitting diode (WLED) has emerged as an alternative nonpharmacological and noninvasive approach to Alzheimer disease (AD). Here, we investigated the therapeutic effects of 40-Hz WLED on psychiatric symptoms (PS) and the contribution of mitochondrial factors in the early stages of sporadic AD (sAD) in rats.
Methods: In male Wistar rats, the AD model was induced via intracerebroventricular (ICV) injection of streptozotocin (STZ). After recovering (7 days) from stereotaxic surgery, 40-Hz WLED exposure was performed for 7 consecutive days lasting 15 min/d. Behavioral (elevated plus maze (EPM), force swim test, and social interaction test), enzymatic, and molecular assays were conducted 24 hours after the last 40-Hz WLED exposure.
Results: Behavioral tasks revealed that 40-Hz WLED exposure in STZ-induced toxicity rats lowered anxiety and depression and increased social interaction. Furthermore, the 40-Hz WLED therapy in STZ-induced toxicity rats increased catalase (CAT) activity in the amygdala, decreased the activity of monoamine oxidases A and B in the whole brain, and increased mitochondrial DNA in the hippocampus.
Conclusion: The current study supports that 40-Hz WLED therapy improved PS and biomarkers in the early stages of sAD. Also, a potential relationship between PS and alterations in mitochondrial markers in certain brain regions seems to exist.
期刊介绍：
BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.
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