一种新出现的污染物--磷酸三(1,3-二氯-2-丙基)酯(TDCIPP)的性别特异性神经毒性和跨代效应。

IF 8.2 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Science of the Total Environment Pub Date : 2024-12-20 Epub Date: 2024-11-22 DOI:10.1016/j.scitotenv.2024.177520
Debora Desantis, Yi Yang, Keng Po Lai, Rudolf S S Wu, Celia Schunter
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引用次数: 0

摘要

阻燃剂(FRs)的生产和使用日益增多,导致其广泛分布于环境中,可能对生态和人类健康构成威胁。磷酸三(1,3-二氯-2-丙基)酯(TDCIPP)是一种常用的阻燃剂,通常存在于水生生态系统中,包括鱼类在内的水生生物可能会在其生命周期的特定阶段或跨代接触到 TDCIPP。在此,我们旨在确定并比较 TDCIPP 对三代(F0 至 F3)雌性和雄性成年海青鱼(Oryzias melastigma)大脑的神经毒性影响。TDCIPP的性别特异性效应与突触传递信号通路和神经元突触可塑性调控有关,在F0雌性的大脑转录组中发现了1917个差异表达基因(DEG),而在F0雄性的大脑转录组中只发现了5个差异表达基因。然而,三代(F0 至 F3)的慢性接触表明,TDCIPP 对雌雄青鳉都有神经毒性作用,雄性青鳉在长期接触后会改变其先天免疫反应和视觉感知。最后,雌性青鳉在 F3 阶段表现出了跨代效应的信号,表现为 2347 个 DEGs(包括表观遗传调控基因)的转录调整增加。这一结果是由于祖先仅在 F0 期暴露于 TDCIPP,而在 F1 期和 F2 期没有直接暴露于 TDCIPP。我们的研究结果表明,即使短暂暴露于 TDCIPP 也会产生长期影响,对海洋生物和其他脊椎动物构成重大风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex-specific neurotoxicity and transgenerational effects of an emerging pollutant, tris(1,3-dichloro-2-propyl)phosphate (TDCIPP).

The growing production and usage of flame retardants (FRs) results in their extensive environmental distribution, potentially posing a threat on both ecological and human health. Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP), a commonly used FR, is commonly found in aquatic ecosystems, and aquatic organisms, including fish, may be exposed to TDCIPP during specific stages of their life cycles, or across generations. Here, we aim to identify and compare the neurotoxic effects of TDCIPP on the brains of female and male adult marine medaka (Oryzias melastigma) across three generations (F0 to F3). Sex-specific effects of TDCIPP related to synaptic transmission signaling pathways and regulation of neuronal synaptic plasticity underlying 1917 differentially expressed genes (DEGs) were evident in the brain transcriptomes of F0 females, while only five DEGs were found in F0 males. However, chronic exposure over three generations (F0 to F3) revealed neurotoxic effects of TDCIPP on both sexes with males altering their innate immune response and visual perception upon prolonged exposure. Lastly, female medaka exhibited signals of transgenerational effects at the F3, as shown by increased transcriptional adjustments of 2347 DEGs including epigenetic regulatory genes. This outcome resulted from the ancestral exposure to TDCIPP only in F0, without any direct TDCIPP exposure in F1 and F2. Our findings show that even brief exposure to TDCIPP result in long-lasting effects, posing a significant risk to marine organisms and potentially other vertebrates.

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来源期刊
Science of the Total Environment
Science of the Total Environment 环境科学-环境科学
CiteScore
17.60
自引率
10.20%
发文量
8726
审稿时长
2.4 months
期刊介绍: The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.
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