急性心肌梗死患者的时点临床结果:迈向个性化医疗的一步

IF 2.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Kyung Hoon Cho MD, PhD , Seok Oh MD, PhD , Yongwhan Lim MD , Joon Ho Ahn MD, PhD , Seung Hun Lee MD, PhD , Dae Young Hyun MD, PhD , Min Chul Kim MD, PhD , Doo Sun Sim MD, PhD , Young Joon Hong MD, PhD , Ju Han Kim MD, PhD , Youngkeun Ahn MD, PhD , Jang Hoon Lee MD, PhD , Chang-Whan Yoon MD, PhD , Sang Rok Lee MD, PhD , Joo-Yong Hahn MD, PhD , Jin-Ok Jeong MD, PhD , Weon Kim MD, PhD , Jin-Yong Hwang MD, PhD , Myung Ho Jeong MD, PhD , Korea Acute Myocardial Infarction Registry (KAMIR)-National Institutes of Health (NIH) Investigators
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引用次数: 0

摘要

有关急性冠状动脉综合征后时间点风险分层模型的数据有限。本研究旨在调查急性心肌梗死患者的时点死亡率,重点是比较真实世界队列中的心肌梗死类型。研究分析了来自韩国全国登记处的 12836 名患者。计算了ST段抬高型心肌梗死(STEMI)和非ST段抬高型心肌梗死(NSTEMI)患者入院后每年、每月和每周时间点的死亡率,将特定时期的死亡人数除以同一时期的高危患者人数。入院后第一周,STEMI 患者的死亡率明显高于 NSTEMI 患者(4.62% 对 1.79%,P<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Time-Point Clinical Outcomes in Patients With Acute Myocardial Infarction: One Step for Personalized Medicine
Limited data exist regarding time-point risk stratification models after acute coronary syndrome. This study aimed to investigate time-point mortality rates in patients with acute myocardial infarction, focusing on comparison by type of myocardial infarction, in a real-world cohort. A total of 12,836 patients from a nationwide Korean registry were analyzed. Mortality rates at yearly, monthly, and weekly time points after admission were calculated by dividing the number of deaths during a specific period by the number of patients at risk in the same period for ST-elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) groups. In the first week after admission, patients with STEMI had a significantly higher mortality rate than patients with NSTEMI (4.62% vs 1.79%, p <0.001). However, this trend was inverted since the second week. The higher mortality rate in patients with STEMI versus NSTEMI was inverted since the second week for male patients but only since the tenth week for female patients. Temporal assessment of correlates of mortality revealed that several baseline variables, including Killip class, systolic blood pressure, total cholesterol, and STEMI diagnosis, had significantly different effects on deaths over time. In conclusion, temporal assessment of time-point outcomes from the Korean registry revealed that an initially higher mortality rate in patients with STEMI versus NSTEMI was inverted in the second week. This outcome assessment could be a step toward developing an advanced risk prediction model for time-course personalized medicine. Further studies are needed to clarify this issue.
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来源期刊
American Journal of Cardiology
American Journal of Cardiology 医学-心血管系统
CiteScore
4.00
自引率
3.60%
发文量
698
审稿时长
33 days
期刊介绍: Published 24 times a year, The American Journal of Cardiology® is an independent journal designed for cardiovascular disease specialists and internists with a subspecialty in cardiology throughout the world. AJC is an independent, scientific, peer-reviewed journal of original articles that focus on the practical, clinical approach to the diagnosis and treatment of cardiovascular disease. AJC has one of the fastest acceptance to publication times in Cardiology. Features report on systemic hypertension, methodology, drugs, pacing, arrhythmia, preventive cardiology, congestive heart failure, valvular heart disease, congenital heart disease, and cardiomyopathy. Also included are editorials, readers'' comments, and symposia.
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