Kseniya V. Serebrennikova, Nadezhda S. Komova, Lyubov V. Barshevskaya, Anatoly V. Zherdev, Boris B. Dzantiev
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Highly sensitive SERS-based lateral flow immunoassay of fipronil using bimetallic Au@Ag@Ag nanorods
A bimetallic core–shell-shell nanorods structure with gap-embedded Raman reporter 5,5′-dithio-bis-(2-nitrobenzoic acid) (DTNB) was developed and applied as a SERS-active nanotag in surface-enhanced Raman scattering lateral flow immunoassay (SERS-LFIA) of the insecticide fipronil. Due to the strong SERS signal of the AuDTNB@AgDTNB@AgNRods, fipronil is detected with extremely low detection limit of 4.6 pg/mL. To the best of our knowledge, the proposed technique is the first SERS-LFIA of fipronil, proven to be effective in the selective determination of the target analyte and capable of detecting fipronil in a matrix of food samples (cucumber and apple juice) with recoveries of 97.0–117.0%. Moreover, the applied functionalization of the SERS nanotag with anti-species antibodies has provided a versatile immunoprobe that could improve performance of different LFIAs.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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