利用基于吲哚的氢键开关实现光电和氧化还原触发的阴离子离通传输

IF 3.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2024-11-01 eCollection Date: 2024-11-12 DOI:10.1021/acsomega.4c07880

Manzoor Ahmad, Andrew Muir, Matthew J Langton

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引用次数: 0

摘要

报告中介绍了一种刺激响应型吲哚基氢键开关，它能在光和氧化还原触发器的作用下，实现跨膜离子转运的开关激活。这是通过邻硝基苄基和偶氮苯笼子对通过分子内氢键预组织的吲哚基阴离子团进行烷基化而实现的。通过形成六元分子内氢键相互作用和锁定阴离子结合质子，使阴离子团失去活性。在与生物相关的光和氧化还原刺激下进行解分级，可通过解除氢键供体的锁定，有效激活阴离子在脂质双分子层膜上的转运，从而使其可用于阴离子的结合和转运。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Off-On Photo- and Redox-Triggered Anion Transport Using an Indole-Based Hydrogen Bond Switch.

A stimulus-responsive indole-based hydrogen bonding switch is reported, which enables off-on activation of transmembrane ion transport in response to photo- and redox triggers. This is achieved by alkylation of an indole-based anionophore, preorganized through intramolecular hydrogen bonding, with o-nitrobenzyl and azobenzene cages. This renders the anionophore inactive through formation of a six-membered intramolecular hydrogen bonding interaction and locking of the anion binding protons. Decaging with biologically relevant light and redox stimuli leads to efficient activation of anion transport across lipid bilayer membranes by unlocking the hydrogen bond donors, such that they are now available for anion binding and transport.

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.