18F-Florzolotau正电子发射计算机断层成像揭示了路易体痴呆症的Tau病理学。

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2024-11-18 DOI:10.1002/mds.30055

Gan Tang, Jia-Ying Lu, Xin-Yi Li, Rui-Xin Yao, Yu-Jie Yang, Fang-Yang Jiao, Ming-Jia Chen, Xiao-Niu Liang, Zi-Zhao Ju, Jing-Jie Ge, Yi-Xin Zhao, Bo Shen, Ping Wu, Yi-Min Sun, Jian-Jun Wu, Tzu-Chen Yen, Chuantao Zuo, Jian Wang, Qian-Hua Zhao, Hui-Wei Zhang, Feng-Tao Liu

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引用次数: 0

摘要

背景：路易体痴呆（DLB）通常表现出复杂的神经病理学，与阿尔茨海默病（AD）具有共同的特征，包括tau聚集。然而，使用18F-AV-1451 tau示踪剂进行的研究显示，DLB中tau病理的程度和地形分布结果并不一致：我们的目的是阐明DLB中tau沉积的地形模式，并通过18F-Florzolotau正电子发射断层扫描（PET）成像研究DLB和AD的体内病理区别：这项横断面研究纳入了DLB患者（24人）、AD患者（43人）和认知健康对照组（18人）。研究人员进行了临床评估和18F-Florzolotau PET成像。使用标准化摄取值比率和体素分析对PET图像上的18F-Florzolotau结合进行定量评估：18F-Florzolotau正电子发射计算机断层成像显示，在DLB患者的不同皮质区域存在广泛的tau沉积，发现了不同的地形模式。在患者中，54.17%的患者表现出与AD相似的模式，而16.67%的患者则表现出不同的模式。与AD相比，DLB表现出独特的体内神经病理学特征，其特点是tau蛋白负荷较低、地形分布不均以及颞叶内侧在tau病理学中的特殊作用：结论：18F-Florzolotau PET成像阐明了DLB的tau病理模式，为未来体内病理分化和潜在的疾病调整疗法提供了宝贵的见解。© 2024 国际帕金森和运动障碍协会。

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¹⁸F-Florzolotau PET Imaging Unveils Tau Pathology in Dementia with Lewy Bodies.

Background: Dementia with Lewy bodies (DLB) commonly exhibits a complex neuropathology, sharing characteristics with Alzheimer's disease (AD), including tau aggregates. However, studies using the ¹⁸F-AV-1451 tau tracer have shown inconsistent findings regarding both the extent and topographical distribution of tau pathology in DLB.

Objectives: Our aim was to elucidate the topographical patterns of tau deposition in DLB and to investigate the in vivo pathological distinction between DLB and AD in virtue of the ¹⁸F-Florzolotau positron emission tomography (PET) imaging.

Methods: This cross-sectional study enrolled patients with DLB (n = 24), AD (n = 43), and cognitively healthy controls (n = 18). Clinical assessments and ¹⁸F-Florzolotau PET imaging were performed. ¹⁸F-Florzolotau binding was quantitatively assessed on PET images using standardized uptake value ratios and voxel-wise analysis.

Results: ¹⁸F-Florzolotau PET imaging revealed widespread tau deposition across various cortical regions in DLB, uncovering heterogeneous topographical patterns. Among patients, 54.17% showed patterns similar to AD, whereas 16.67% exhibited distinct patterns. Compared to AD, DLB exhibited a unique in vivo neuropathological profile, characterized by a lower tau protein burden, heterogeneous topographical distributions, and a specific role of the medial temporal lobe in tau pathology.

Conclusions: ¹⁸F-Florzolotau PET imaging elucidated tau pathology patterns in DLB, providing valuable insights for future in vivo pathological differentiation and potential disease-modifying therapies. © 2024 International Parkinson and Movement Disorder Society.

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.