用碘-131 直接标记金纳米粒子,用于肿瘤放射性核素治疗。

IF 6.6 2区 医学 Q1 NANOSCIENCE & NANOTECHNOLOGY
International Journal of Nanomedicine Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S484976
Meilin Zhu, Lingzhou Zhao, Xia Lu
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引用次数: 0

摘要

目的:金纳米粒子(Au NPs)被广泛用作多功能模板,用于开发疾病诊断和治疗的多功能纳米系统。碘可以通过化学吸附作用与金结合,这使得用放射性碘标记金纳米粒子成为一种简单的方法。然而,对肿瘤放射性核素治疗的评估还不够充分。在这项研究中,我们探讨了吸附 131I 的 Au NPs 作为新型纳米探针用于肿瘤放射性核素治疗的可行性:将 Au NPs 与 131I 混合进行放射性标记,在不同温度、pH 值和 131I 浓度等条件下分析吸附 131I 的 Au NPs 的放射化学纯度(RCP)和体外稳定性。采用皮下注射肿瘤模型评估了吸附 131I 的 Au NPs 的肿瘤蓄积和治疗潜力:数据显示,金氧化物对 131I 的化学吸附是即时、特异和定量的。吸附了 131I 的 Au NPs 在不同介质中表现出较高的体外稳定性,在体外对肿瘤细胞有明显的抑制作用,具有良好的保留能力,在体内向肿瘤小鼠进行瘤内注射后具有治疗效果:我们的研究表明,金氧化物和放射性碘的化学吸附作为一种构建各种治疗应用纳米系统的策略,具有巨大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy.

Purpose: Gold nanoparticles (Au NPs) are widely used as versatile templates to develop multifunctional nanosystems for disease diagnosis and treatment. Iodine can bind to gold via chemisorption, making this a simple method for labeling Au NPs with radioactive iodine. However, the evaluation of tumor radionuclide therapy is insufficient. In this study, we investigated the feasibility of 131I-adsorbed Au NPs as novel nanoprobes for tumor radionuclide therapy.

Materials and methods: Radiolabeling was performed by mixing Au NPs and 131I, and the radiochemical purity (RCP) and in vitro stability of 131I-adsorbed Au NPs were analyzed under different conditions, including various temperatures, pH values, and 131I concentrations. The tumor accumulation and therapeutic potential of 131I-adsorbed Au NPs were assessed using a subcutaneous tumor model after intratumoral injection.

Results: The data showed that the chemisorption of the Au NPs onto 131I was instant, specific, and quantitative. The 131I-adsorbed Au NPs exhibited high in vitro stability in different media, distinct inhibitory effects on tumor cells in vitro, good retention ability, and therapeutic effects after intratumoral injection into tumor-bearing mice in vivo.

Conclusion: Our work demonstrates that chemisorption of Au NPs and radioiodine has great potential as a strategy for constructing various nanosystems for theranostic applications.

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来源期刊
International Journal of Nanomedicine
International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY
CiteScore
14.40
自引率
3.80%
发文量
511
审稿时长
1.4 months
期刊介绍: The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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