Xuan Zhou, Xunzhou Yu, Tingting You, Baohua Zhao, Lanlan Dong, Can Huang, Xiaoqing Zhou, Malcolm Xing, Wei Qian, Gaoxing Luo
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引用次数: 0
摘要
皮肤伤口已成为影响人类健康和加重全球医疗负担的重要问题。与天然细胞外基质(ECM)相似的水凝胶材料是理想伤口敷料的最佳候选材料之一,也是打印墨水最可行的选择。传统技术制造的水凝胶缺乏仿生和机械特性,而三维打印技术则不同,它能迅速、准确地制造出具有复杂生物活性结构的水凝胶,并具有促进组织再生和伤口愈合的潜力。本文全面综述了基于 3D 打印技术的多功能水凝胶敷料在伤口愈合方面的应用。综述首先总结了伤口水凝胶敷料的三维打印技术,包括光固化、挤出、喷墨和激光辅助三维打印。然后,介绍了用于三维打印伤口水凝胶敷料的一系列由天然聚合物、合成聚合物和复合聚合物组成的生物墨水的特性和设计方法。之后,深入讨论了基于 3D 打印的多功能水凝胶敷料在各种伤口环境中的应用,包括止血、消炎、抗菌、皮肤附属器官再生、智能监测和机器学习辅助治疗。最后,介绍了基于 3D 打印的水凝胶敷料在伤口愈合方面面临的挑战和前景。
3D Printing-Based Hydrogel Dressings for Wound Healing
Skin wounds have become an important issue that affects human health and burdens global medical care. Hydrogel materials similar to the natural extracellular matrix (ECM) are one of the best candidates for ideal wound dressings and the most feasible choices for printing inks. Distinct from hydrogels made by traditional technologies, which lack bionic and mechanical properties, 3D printing can promptly and accurately create hydrogels with complex bioactive structures and the potential to promote tissue regeneration and wound healing. Herein, a comprehensive review of multi-functional 3D printing-based hydrogel dressings for wound healing is presented. The review first summarizes the 3D printing techniques for wound hydrogel dressings, including photo-curing, extrusion, inkjet, and laser-assisted 3D printing. Then, the properties and design approaches of a series of bioinks composed of natural, synthetic, and composite polymers for 3D printing wound hydrogel dressings are described. Thereafter, the application of multi-functional 3D printing-based hydrogel dressings in a variety of wound environments is discussed in depth, including hemostasis, anti-inflammation, antibacterial, skin appendage regeneration, intelligent monitoring, and machine learning-assisted therapy. Finally, the challenges and prospects of 3D printing-based hydrogel dressings for wound healing are presented.
期刊介绍:
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.