6-59 个月营养不良和非营养不良儿童体内 25- 羟维生素 D 与肠道和全身炎症指标之间的关系。

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-11-16 DOI:10.1016/j.cyto.2024.156807

Janet Adede Carboo, Linda Malan, Martani Lombard, Arista Nienaber, Robin Claire Dolman-Macleod

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引用次数: 0

摘要

背景：炎症加剧会导致儿童生长迟缓。维生素 D（vitD）可抑制促炎症反应，增强抗炎症分子的生成，因此维生素 D 缺乏症（VDD）与炎症反应加剧有关。在营养不良的儿童中，维生素 D 缺乏和炎症是并存的，但人们对它们之间的相互作用知之甚少：本横断面研究旨在调查营养不良儿童和非营养不良儿童血清 25- 羟基维生素 D（25（OH）D）浓度与炎症指标的关系，以及在嵌套前后试验中补充维生素 D 对低 25（OH）D 儿童炎症指标的影响：方法：横断面测量 121 名营养不良儿童和 51 名 6-59 个月非营养不良儿童的血清 25（OH）D、IL-1β、IL-8、IL-10、TNF-α、CRP、AGP、IFABP、sCD14、IGF-1 和 FGF-21。儿童的血清 25(OH)D 结果：有血清 25（OH）D 的儿童的 TNF-α 和 FGF-21 均高于营养不良的儿童：优化维生素 D 状态可能是减少全身和肠道炎症，进而改善生长状况的一种策略，尤其是在营养不良的儿童中。

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The relationship between 25-hydroxyvitamin D and markers of intestinal and systemic inflammation in undernourished and non-undernourished children, 6–59 months

Background

Elevated inflammation contributes to growth faltering in children. Vitamin D (vitD) suppresses pro-inflammatory and enhances anti-inflammatory molecule production, thus vitamin D deficiency (VDD) has been associated with heightened inflammation. In undernourished children, VDD and inflammation co-exist, however, little is known about their interaction.

Objective

This cross-sectional study aimed to investigate the association of serum 25-hydroxyvitamin D (25(OH)D) concentration with markers of inflammation in undernourished and non-undernourished children, as well as the effect of vitD supplementation on inflammatory markers in the children with low 25(OH)D in a nested before-and-after trial.

Methods

Serum 25(OH)D, IL-1β, IL-8, IL-10, TNF-α, CRP, AGP, IFABP, sCD14, IGF-1 and FGF-21 of 121 undernourished and 51 non-undernourished children aged 6–59 months were measured cross-sectionally. Children with serum 25(OH)D < 30 ng/mL received 50,000 IU/week of vitD for three weeks.

Results

TNF-α and FGF-21 in the overall and undernourished group were higher in those with serum 25(OH)D < 30 ng/mL compared to those with serum ≥ 30 ng/mL (p < 0.05), while IFABP concentration was higher in the non-undernourished children with serum 25(OH)D < 30 ng/mL (p = 0.047). Serum 25(OH)D was negatively associated with TNF-α in the overall group (β = −0.012, p = 0.034); and FGF-21 (β = −0.013, p = 0.023) in the undernourished group. After the supplementation trial, TNF-α was reduced by 55.9 % (p = 0.008) and 64.7 % (p = 0.017) in the overall and undernourished groups respectively, and AGP showed a trend of 41.6 % reduction (p = 0.099) in the overall group. IL-1β concentration increased post-supplementation in the overall (p = 0.011) and undernourished groups (p = 0.039).

Conclusion

Optimising vitD status may potentially be a strategy for reducing systemic and gut inflammation, and subsequently improving growth, particularly in undernourished children.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.