高原大麦中 2-(2-苯基乙基)铬酮衍生物的结构特征和肝保护活性 Monascus purpureus

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2024-11-06 DOI:10.1007/s10600-024-04509-x

Rongrui Wei, Jiazeng Guo, Wemin Liu, Huaqiang Wu, Qinge Ma

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引用次数: 0

摘要

首次从高原大麦Monascus purpureus中分离出了一种新的2-(2-苯基乙基)铬酮衍生物，命名为6,7-二甲氧基-2-[2-(3′,4′,5′-三甲氧基苯基)乙基]铬酮(1)，以及8种已知的2-(2-苯基乙基)铬酮衍生物(2-9)。通过大量光谱数据和已报道的参考文献确定了化合物 1-9，并以 Bifendatatum 为阳性药物对它们在 L-O2 细胞上的保肝活性进行了评估。结果表明，化合物 1、4 和 8 具有一定的保肝活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Structural Characterization and Hepatoprotective Activities of 2-(2-Phenylethyl)Chromone Derivatives from Highland Barley Monascus purpureus

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Structural Characterization and Hepatoprotective Activities of 2-(2-Phenylethyl)Chromone Derivatives from Highland Barley Monascus purpureus

A novel 2-(2-phenylethyl)chromone derivative, named 6,7-dimethoxy-2-[2-(3′ ,4′ ,5′ -trimethoxyphenyl)ethyl]chromone (1), and eight known 2-(2-phenylethyl)chromone derivatives (2–9) were isolated from highland barley Monascus purpureus for the first time. Compounds 1–9 were determined by extensive spectroscopic data and reported references and they were evaluated for their hepatoprotective activities on L-O2 cells with Bifendatatum as the positive drug. As a result, compounds 1, 4, and 8 exhibited certain hepatoprotective activities.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.