J.C. Brown, R. Boat, N.C. Williams, M.A. Johnson, G.R. Sharpe
{"title":"在二氧化碳呼吸挑战中,事先的自我控制用力会降低前额叶皮层的含氧量,但不会影响对呼吸困难或耐受时间的感知。","authors":"J.C. Brown, R. Boat, N.C. Williams, M.A. Johnson, G.R. Sharpe","doi":"10.1016/j.resp.2024.104371","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Dyspnoea perception is influenced by a complex interplay of physiological, psychological, and environmental factors. Recently, we showed that males with high trait self-control experience less dyspnoea and persist for longer in a carbon dioxide (CO<sub>2</sub>) rebreathing challenge than males with low trait self-control. As self-control can also vary within individuals (state self-control), the primary aim of the present study was to investigate whether prior self-control exertion influenced perceptions of dyspnoea and tolerance of a CO<sub>2</sub> rebreathing challenge in healthy young males. We also used functional near-infrared spectroscopy (fNIRS) to assess haemodynamic activity of the pre-frontal cortex (PFC) which is a region of interest (ROI) in dyspnoea research, and the primary brain region associated with exertion of self-control.</div></div><div><h3>Methods</h3><div>In a within-subjects design, fifteen healthy young males completed an easy (congruent) Stroop task (control condition) and a difficult (incongruent) Stroop task (prior self-control exertion, experimental condition) followed by a CO<sub>2</sub> rebreathing challenge until the limit of tolerance. Changes in oxyhaemoglobin (ΔO<sub>2</sub>Hb) and deoxyhaemoglobin (ΔHHb) were assessed continuously in the Stroop task and CO<sub>2</sub> rebreathing challenge. During the CO<sub>2</sub> rebreathing challenge, dyspnoea intensity and unpleasantness were rated every 30 s.</div></div><div><h3>Results</h3><div>Prior self-control exertion did not affect perceptions of dyspnoea or tolerance time in the CO<sub>2</sub> rebreathing challenge (all <em>P</em> > 0.05). ΔO<sub>2</sub>Hb from baseline was higher in the left (+38 %) and right (+44 %) pre-frontal cortices during the difficult Stroop task than the easy Stroop task (both <em>P</em> < 0.05). During the subsequent CO<sub>2</sub> rebreathing challenge, ΔO<sub>2</sub>Hb was attenuated following prior self-control exertion in the left PFC.</div></div><div><h3>Conclusions</h3><div>Although prior self-control exertion decreased pre-frontal cortex oxygenation during a subsequent CO<sub>2</sub> rebreathing challenge, there was no change in tolerance time or perceptions of dyspnoea.</div></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"332 ","pages":"Article 104371"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prior self-control exertion decreases pre-frontal cortex oxygenation during a CO2 rebreathing challenge but does not affect perceptions of dyspnoea or tolerance time\",\"authors\":\"J.C. Brown, R. Boat, N.C. Williams, M.A. Johnson, G.R. Sharpe\",\"doi\":\"10.1016/j.resp.2024.104371\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Dyspnoea perception is influenced by a complex interplay of physiological, psychological, and environmental factors. Recently, we showed that males with high trait self-control experience less dyspnoea and persist for longer in a carbon dioxide (CO<sub>2</sub>) rebreathing challenge than males with low trait self-control. As self-control can also vary within individuals (state self-control), the primary aim of the present study was to investigate whether prior self-control exertion influenced perceptions of dyspnoea and tolerance of a CO<sub>2</sub> rebreathing challenge in healthy young males. We also used functional near-infrared spectroscopy (fNIRS) to assess haemodynamic activity of the pre-frontal cortex (PFC) which is a region of interest (ROI) in dyspnoea research, and the primary brain region associated with exertion of self-control.</div></div><div><h3>Methods</h3><div>In a within-subjects design, fifteen healthy young males completed an easy (congruent) Stroop task (control condition) and a difficult (incongruent) Stroop task (prior self-control exertion, experimental condition) followed by a CO<sub>2</sub> rebreathing challenge until the limit of tolerance. Changes in oxyhaemoglobin (ΔO<sub>2</sub>Hb) and deoxyhaemoglobin (ΔHHb) were assessed continuously in the Stroop task and CO<sub>2</sub> rebreathing challenge. During the CO<sub>2</sub> rebreathing challenge, dyspnoea intensity and unpleasantness were rated every 30 s.</div></div><div><h3>Results</h3><div>Prior self-control exertion did not affect perceptions of dyspnoea or tolerance time in the CO<sub>2</sub> rebreathing challenge (all <em>P</em> > 0.05). ΔO<sub>2</sub>Hb from baseline was higher in the left (+38 %) and right (+44 %) pre-frontal cortices during the difficult Stroop task than the easy Stroop task (both <em>P</em> < 0.05). During the subsequent CO<sub>2</sub> rebreathing challenge, ΔO<sub>2</sub>Hb was attenuated following prior self-control exertion in the left PFC.</div></div><div><h3>Conclusions</h3><div>Although prior self-control exertion decreased pre-frontal cortex oxygenation during a subsequent CO<sub>2</sub> rebreathing challenge, there was no change in tolerance time or perceptions of dyspnoea.</div></div>\",\"PeriodicalId\":20961,\"journal\":{\"name\":\"Respiratory Physiology & Neurobiology\",\"volume\":\"332 \",\"pages\":\"Article 104371\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Respiratory Physiology & Neurobiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1569904824001642\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory Physiology & Neurobiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1569904824001642","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Prior self-control exertion decreases pre-frontal cortex oxygenation during a CO2 rebreathing challenge but does not affect perceptions of dyspnoea or tolerance time
Introduction
Dyspnoea perception is influenced by a complex interplay of physiological, psychological, and environmental factors. Recently, we showed that males with high trait self-control experience less dyspnoea and persist for longer in a carbon dioxide (CO2) rebreathing challenge than males with low trait self-control. As self-control can also vary within individuals (state self-control), the primary aim of the present study was to investigate whether prior self-control exertion influenced perceptions of dyspnoea and tolerance of a CO2 rebreathing challenge in healthy young males. We also used functional near-infrared spectroscopy (fNIRS) to assess haemodynamic activity of the pre-frontal cortex (PFC) which is a region of interest (ROI) in dyspnoea research, and the primary brain region associated with exertion of self-control.
Methods
In a within-subjects design, fifteen healthy young males completed an easy (congruent) Stroop task (control condition) and a difficult (incongruent) Stroop task (prior self-control exertion, experimental condition) followed by a CO2 rebreathing challenge until the limit of tolerance. Changes in oxyhaemoglobin (ΔO2Hb) and deoxyhaemoglobin (ΔHHb) were assessed continuously in the Stroop task and CO2 rebreathing challenge. During the CO2 rebreathing challenge, dyspnoea intensity and unpleasantness were rated every 30 s.
Results
Prior self-control exertion did not affect perceptions of dyspnoea or tolerance time in the CO2 rebreathing challenge (all P > 0.05). ΔO2Hb from baseline was higher in the left (+38 %) and right (+44 %) pre-frontal cortices during the difficult Stroop task than the easy Stroop task (both P < 0.05). During the subsequent CO2 rebreathing challenge, ΔO2Hb was attenuated following prior self-control exertion in the left PFC.
Conclusions
Although prior self-control exertion decreased pre-frontal cortex oxygenation during a subsequent CO2 rebreathing challenge, there was no change in tolerance time or perceptions of dyspnoea.
期刊介绍:
Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense.
Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as:
-Mechanics of breathing-
Gas exchange and acid-base balance-
Respiration at rest and exercise-
Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen-
Embryonic and adult respiration-
Comparative respiratory physiology.
Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.