[TNBC IV 期:从标准方案到 ADC 新时代,患者的心路历程]。

Q3 Medicine
Laura Iezzi
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引用次数: 0

摘要

三阴性乳腺癌(TNBC)仍然是乳腺癌中最具侵袭性的分子亚型,而最佳治疗方法仍然是一项挑战。由于缺乏 "传统 "的分子靶点,几十年来,全身治疗的特点一直是使用传统的细胞毒性药物。近年来的研究证明,TNBC 并不是一种缺乏特定特征的单一病理类型,而是具有不同遗传学、组织学和临床改变的不同实体。随着多种抗肿瘤药物(包括抗体药物共轭物 (ADC))获得批准,该病的治疗管理得以优化和改善。我们介绍的临床病例展示了一名转移性 TNBC 患者的 "心路历程",以及多年来从标准方案到创新策略的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[TNBC, stage IV: a patient's journey, from standard options to the new era of ADC.]

Triple-negative breast cancer (TNBC) continues to be the most aggressive molecular subtype of breast cancer and the optimal therapeutic management is still a challenge. Due to the lack of "traditional" molecular targets, for decades, systemic treatment has been characterized by the use of classic cytotoxic drugs. In recent years, it has been proved that TNBC is not represented by a single pathology lack of specific features, but of different entities with distinct genetic, histological and clinical alterations. This allowed to optimize and improve the therapeutic management of the disease, with the approval of multiple anti-tumor agents, including antibody-drug conjugates (ADC). The clinical case we present illustrates the "journey" of a patient affected by metastatic TNBC, of the therapeutic choices made among the options available over the years, from the standard options to the innovative strategies.

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来源期刊
Recenti progressi in medicina
Recenti progressi in medicina Medicine-Medicine (all)
CiteScore
0.90
自引率
0.00%
发文量
143
期刊介绍: Giunta ormai al sessantesimo anno, Recenti Progressi in Medicina continua a costituire un sicuro punto di riferimento ed uno strumento di lavoro fondamentale per l"ampliamento dell"orizzonte culturale del medico italiano. Recenti Progressi in Medicina è una rivista di medicina interna. Ciò significa il recupero di un"ottica globale e integrata, idonea ad evitare sia i particolarismi della informazione specialistica sia la frammentazione di quella generalista.
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