{"title":"[萨妥珠单抗-戈维替康在三阴性乳腺癌患者治疗过程中的应用:一个前沿故事。]","authors":"Simona Frezzini","doi":"10.1701/4365.43613","DOIUrl":null,"url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) poses a challenge due to high metastatic potential and few care options. The successful management of relapsed disease is an unmet clinical need, to date. The antibody drug conjugate sacituzumab govitecan (SG) has been an actual breakthrough in the metastatic TNBC (mTNBC) algorithm. Herein, we report the case of a 45-year-old patient, who was referred to our centre for a hard-to-treat locoregional relapse from TNBC, thus receiving SG in third-line setting for 15 months. We also discuss clinical presentation, treatment patterns and outcomes along with a brief literature review. Our case study outlines the long-term efficacy of third-line SG in a TNBC patient with a refractory disease. Thanks to SG use within a multimodal patient journey, a sustained disease control along with a preserved quality of life was gained. Further real-world data is awaited to confirm these findings.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"94e-98e"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Sacituzumab govitecan in a triple-negative breast cancer patient journey: a cutting-edge story.]\",\"authors\":\"Simona Frezzini\",\"doi\":\"10.1701/4365.43613\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Triple-negative breast cancer (TNBC) poses a challenge due to high metastatic potential and few care options. The successful management of relapsed disease is an unmet clinical need, to date. The antibody drug conjugate sacituzumab govitecan (SG) has been an actual breakthrough in the metastatic TNBC (mTNBC) algorithm. Herein, we report the case of a 45-year-old patient, who was referred to our centre for a hard-to-treat locoregional relapse from TNBC, thus receiving SG in third-line setting for 15 months. We also discuss clinical presentation, treatment patterns and outcomes along with a brief literature review. Our case study outlines the long-term efficacy of third-line SG in a TNBC patient with a refractory disease. Thanks to SG use within a multimodal patient journey, a sustained disease control along with a preserved quality of life was gained. Further real-world data is awaited to confirm these findings.</p>\",\"PeriodicalId\":20887,\"journal\":{\"name\":\"Recenti progressi in medicina\",\"volume\":\"115 11\",\"pages\":\"94e-98e\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Recenti progressi in medicina\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1701/4365.43613\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recenti progressi in medicina","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1701/4365.43613","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
[Sacituzumab govitecan in a triple-negative breast cancer patient journey: a cutting-edge story.]
Triple-negative breast cancer (TNBC) poses a challenge due to high metastatic potential and few care options. The successful management of relapsed disease is an unmet clinical need, to date. The antibody drug conjugate sacituzumab govitecan (SG) has been an actual breakthrough in the metastatic TNBC (mTNBC) algorithm. Herein, we report the case of a 45-year-old patient, who was referred to our centre for a hard-to-treat locoregional relapse from TNBC, thus receiving SG in third-line setting for 15 months. We also discuss clinical presentation, treatment patterns and outcomes along with a brief literature review. Our case study outlines the long-term efficacy of third-line SG in a TNBC patient with a refractory disease. Thanks to SG use within a multimodal patient journey, a sustained disease control along with a preserved quality of life was gained. Further real-world data is awaited to confirm these findings.
期刊介绍:
Giunta ormai al sessantesimo anno, Recenti Progressi in Medicina continua a costituire un sicuro punto di riferimento ed uno strumento di lavoro fondamentale per l"ampliamento dell"orizzonte culturale del medico italiano. Recenti Progressi in Medicina è una rivista di medicina interna. Ciò significa il recupero di un"ottica globale e integrata, idonea ad evitare sia i particolarismi della informazione specialistica sia la frammentazione di quella generalista.