{"title":"高尿酸血症和尿酸/肌酐比值升高与 III/IV 期牙周炎有关：一项基于人群的横断面研究（NHANES，2009-2014 年）。","authors":"Yueqi Chen, Peipei Lu, Chuyin Lin, Song Li, Yufan Zhu, Jiaying Tan, Yinghong Zhou, Ting Yu","doi":"10.1186/s12903-024-05173-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To explore the association between hyperuricemia and having periodontitis.</p><p><strong>Materials and methods: </strong>A representative cross-sectional dataset of 10,158 adults was extracted from the National Health and Nutrition Examination Survey (NHANES) 2009-2014. The association between hyperuricemia (the primary exposure) and having periodontitis (outcome) were evaluated using weighted logistic regression models. Serum uric acid (UA) levels and the UA to creatinine (UA/Cr) ratio were used as secondary exposures. Their associations with the diagnosis periodontitis were analyzed using weighted logistic regression or restricted cubic spline regression.</p><p><strong>Results: </strong>The prevalence of Stages III/IV periodontitis was 47.7% among individuals with hyperuricemia and 37.4% among those without. After adjustment, individuals with hyperuricemia had 0.281 times higher odds of developing Stages III/IV periodontitis compared to those without hyperuricemia (adjusted OR = 1.286, 95% CI = 1.040 to 1.591, P = 0.024). The increased odds could be explained by a linear relationship with the serum UA/Cr ratio and a U-shaped relationship with serum UA levels. Each unit increase in the serum UA/Cr ratio was associated with 0.048 times higher odds of developing Stages III/IV periodontitis (adjusted OR = 1.048, 95% CI = 1.008 to 1.088, P = 0.021). Additionally, each 1 mg/dL increase in serum UA was associated with 0.156 times higher odds (adjusted OR = 1.156, 95% CI = 1.009 to 1.323, P = 0.038) of developing Stages III/IV periodontitis when UA levels were greater than 5.9 mg/dL, but 0.118 times lower odds when UA levels were 5.9 mg/dL or lower (adjusted OR = 0.882, 95% CI = 0.790 to 0.984, P = 0.027). Sensitivity analyses validated the robustness of the findings.</p><p><strong>Conclusions: </strong>This study provides the first direct evidence that hyperuricemia is associated with Stages III/IV periodontitis.</p><p><strong>Clinical relevance: </strong>Hyperuricemia may represent a new potential comorbidity of periodontitis, possibly contributing directly or indirectly to the disease burden in patients with periodontitis.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1389"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566428/pdf/","citationCount":"0","resultStr":"{\"title\":\"Hyperuricemia and elevated uric acid/creatinine ratio are associated with stages III/IV periodontitis: a population-based cross-sectional study (NHANES 2009-2014).\",\"authors\":\"Yueqi Chen, Peipei Lu, Chuyin Lin, Song Li, Yufan Zhu, Jiaying Tan, Yinghong Zhou, Ting Yu\",\"doi\":\"10.1186/s12903-024-05173-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To explore the association between hyperuricemia and having periodontitis.</p><p><strong>Materials and methods: </strong>A representative cross-sectional dataset of 10,158 adults was extracted from the National Health and Nutrition Examination Survey (NHANES) 2009-2014. The association between hyperuricemia (the primary exposure) and having periodontitis (outcome) were evaluated using weighted logistic regression models. Serum uric acid (UA) levels and the UA to creatinine (UA/Cr) ratio were used as secondary exposures. Their associations with the diagnosis periodontitis were analyzed using weighted logistic regression or restricted cubic spline regression.</p><p><strong>Results: </strong>The prevalence of Stages III/IV periodontitis was 47.7% among individuals with hyperuricemia and 37.4% among those without. After adjustment, individuals with hyperuricemia had 0.281 times higher odds of developing Stages III/IV periodontitis compared to those without hyperuricemia (adjusted OR = 1.286, 95% CI = 1.040 to 1.591, P = 0.024). The increased odds could be explained by a linear relationship with the serum UA/Cr ratio and a U-shaped relationship with serum UA levels. Each unit increase in the serum UA/Cr ratio was associated with 0.048 times higher odds of developing Stages III/IV periodontitis (adjusted OR = 1.048, 95% CI = 1.008 to 1.088, P = 0.021). Additionally, each 1 mg/dL increase in serum UA was associated with 0.156 times higher odds (adjusted OR = 1.156, 95% CI = 1.009 to 1.323, P = 0.038) of developing Stages III/IV periodontitis when UA levels were greater than 5.9 mg/dL, but 0.118 times lower odds when UA levels were 5.9 mg/dL or lower (adjusted OR = 0.882, 95% CI = 0.790 to 0.984, P = 0.027). Sensitivity analyses validated the robustness of the findings.</p><p><strong>Conclusions: </strong>This study provides the first direct evidence that hyperuricemia is associated with Stages III/IV periodontitis.</p><p><strong>Clinical relevance: </strong>Hyperuricemia may represent a new potential comorbidity of periodontitis, possibly contributing directly or indirectly to the disease burden in patients with periodontitis.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>\",\"PeriodicalId\":9072,\"journal\":{\"name\":\"BMC Oral Health\",\"volume\":\"24 1\",\"pages\":\"1389\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566428/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Oral Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12903-024-05173-x\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Oral Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12903-024-05173-x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨高尿酸血症与牙周炎之间的关系：探讨高尿酸血症与牙周炎之间的关系：从 2009-2014 年美国国家健康与营养调查（NHANES）中提取了 10,158 名成年人的代表性横断面数据集。采用加权逻辑回归模型评估了高尿酸血症（主要暴露）与牙周炎（结果）之间的关联。血清尿酸（UA）水平和 UA 与肌酐（UA/Cr）比值作为次要暴露。使用加权逻辑回归或限制性立方样条回归分析了它们与牙周炎诊断之间的关系：结果：III/IV 期牙周炎在高尿酸血症患者中的发病率为 47.7%，在非高尿酸血症患者中的发病率为 37.4%。经调整后，高尿酸血症患者患 III/IV 期牙周炎的几率是无高尿酸血症患者的 0.281 倍（调整后 OR = 1.286，95% CI = 1.040 至 1.591，P = 0.024）。血清 UA/Cr 比值呈线性关系，与血清 UA 水平呈 U 型关系，可以解释几率增加的原因。血清 UA/Cr 比率每增加一个单位，患 III/IV 期牙周炎的几率就会增加 0.048 倍（调整后 OR = 1.048，95% CI = 1.008 至 1.088，P = 0.021）。此外，当 UA 水平高于 5.9 mg/dL 时，血清 UA 每增加 1 mg/dL 患 III/IV 期牙周炎的几率增加 0.156 倍（调整 OR = 1.156，95% CI = 1.009 至 1.323，P = 0.038），但当 UA 水平为 5.9 mg/dL 或更低时，患 III/IV 期牙周炎的几率降低 0.118 倍（调整 OR = 0.882，95% CI = 0.790 至 0.984，P = 0.027）。敏感性分析验证了研究结果的稳健性：本研究首次提供了高尿酸血症与 III/IV 期牙周炎相关的直接证据：高尿酸血症可能是牙周炎的一种新的潜在合并症，可能直接或间接加重牙周炎患者的疾病负担：临床试验编号：不适用。
Hyperuricemia and elevated uric acid/creatinine ratio are associated with stages III/IV periodontitis: a population-based cross-sectional study (NHANES 2009-2014).
Objectives: To explore the association between hyperuricemia and having periodontitis.
Materials and methods: A representative cross-sectional dataset of 10,158 adults was extracted from the National Health and Nutrition Examination Survey (NHANES) 2009-2014. The association between hyperuricemia (the primary exposure) and having periodontitis (outcome) were evaluated using weighted logistic regression models. Serum uric acid (UA) levels and the UA to creatinine (UA/Cr) ratio were used as secondary exposures. Their associations with the diagnosis periodontitis were analyzed using weighted logistic regression or restricted cubic spline regression.
Results: The prevalence of Stages III/IV periodontitis was 47.7% among individuals with hyperuricemia and 37.4% among those without. After adjustment, individuals with hyperuricemia had 0.281 times higher odds of developing Stages III/IV periodontitis compared to those without hyperuricemia (adjusted OR = 1.286, 95% CI = 1.040 to 1.591, P = 0.024). The increased odds could be explained by a linear relationship with the serum UA/Cr ratio and a U-shaped relationship with serum UA levels. Each unit increase in the serum UA/Cr ratio was associated with 0.048 times higher odds of developing Stages III/IV periodontitis (adjusted OR = 1.048, 95% CI = 1.008 to 1.088, P = 0.021). Additionally, each 1 mg/dL increase in serum UA was associated with 0.156 times higher odds (adjusted OR = 1.156, 95% CI = 1.009 to 1.323, P = 0.038) of developing Stages III/IV periodontitis when UA levels were greater than 5.9 mg/dL, but 0.118 times lower odds when UA levels were 5.9 mg/dL or lower (adjusted OR = 0.882, 95% CI = 0.790 to 0.984, P = 0.027). Sensitivity analyses validated the robustness of the findings.
Conclusions: This study provides the first direct evidence that hyperuricemia is associated with Stages III/IV periodontitis.
Clinical relevance: Hyperuricemia may represent a new potential comorbidity of periodontitis, possibly contributing directly or indirectly to the disease burden in patients with periodontitis.
期刊介绍：
BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.
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