TEX264 介导的选择性自噬可引导 DNA 损伤修复。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-11-15 DOI:10.1016/j.tibs.2024.10.012

Yuxia Qi, Sho W Suzuki

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引用次数: 0

摘要

DNA 经常受到内源性和外源性因素的损伤，从而导致突变和疾病。DNA 传统上是在细胞核中修复的，而 Lascaux 等人揭示了溶酶体在 DNA 修复中的新作用，证明拓扑异构酶 1（TOP1）裂解复合体（TOP1cc）DNA 病变是通过 TEX264 介导的选择性自噬降解的。

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查看原文本刊更多论文

TEX264-mediated selective autophagy directs DNA damage repair.

DNA is constantly subject to damage from endogenous and exogenous factors, leading to mutations and disease. While DNA is traditionally repaired in the nucleus, Lascaux et al. reveal a novel role for the lysosome in DNA repair, demonstrating that topoisomerase 1 (TOP1) cleavage complex (TOP1cc) DNA lesions are degraded via TEX264-mediated selective autophagy.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.