纳米材料通过影响泛素-蛋白酶体系统发挥生物效应

IF 6 2区医学 Q1 CHEMISTRY, MEDICINAL

European Journal of Medicinal Chemistry Pub Date : 2024-11-15 DOI:10.1016/j.ejmech.2024.116974

Zhen Ai, Dan Li, Shuquan Lan, Chao Zhang

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引用次数: 0

摘要

泛素-蛋白酶体系统（UPS）是蛋白质翻译后修饰的一种重要类型，它影响各种蛋白质的数量和质量，并影响细胞周期、转录、氧化应激和自噬等细胞过程。纳米材料（NMs）具有优异的物理化学特性，可直接与 UPS 相互作用，并作为分子靶向药物诱导生物过程的变化。本综述概述了 NMs 对折叠错误蛋白质和关键蛋白质的 UPS 的影响，这些蛋白质与癌症、神经退行性疾病和氧化应激有关。这篇综述还总结了参与泛素化的修饰过程对 NMs 生物效应的作用，以及 NMs 通过调节 UPS 产生这种效应的机制。这篇综述加深了我们对 NMs 对蛋白质降解过程的影响的理解，并为疾病提供了新的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nanomaterials exert biological effects by influencing the ubiquitin-proteasome system

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Nanomaterials exert biological effects by influencing the ubiquitin-proteasome system

The ubiquitin-proteasome system (UPS) is an important type of protein post-translational modification that affects the quantity and quality of various proteins and influences cellular processes such as the cell cycle, transcription, oxidative stress, and autophagy. Nanomaterials (NMs), which exhibit excellent physicochemical properties, can directly interact with the UPS and act as molecular-targeted drugs to induce changes in biological processes. This review provides an overview of the influence of NMs on the UPS of misfolded proteins and key proteins, which are related to cancer, neurodegenerative diseases and oxidative stress. This review also summarizes the role of modification processes involved in ubiquitination the biological effects of NMs and the mechanism of such effects of NMs through regulation of the UPS. This review deepens our understanding of the influence of NMs on the protein degradation process and provides new potential therapeutic targets for disease.

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来源期刊

European Journal of Medicinal Chemistry 化学-医药化学

CiteScore

11.70

自引率

9.00%

发文量

863

审稿时长

29 days

期刊介绍： The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.