基于辐射响应性纳米微粒的时空并发 PARP 抑制剂增敏技术用于肺癌化放疗（Adv.）

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2024-11-11 DOI:10.1002/adhm.202470177

Fei Kang, Meng Niu, Zijian Zhou, Mingru Zhang, Hehe Xiong, Fantian Zeng, Jing Wang, Xiaoyuan Chen

{"title":"基于辐射响应性纳米微粒的时空并发 PARP 抑制剂增敏技术用于肺癌化放疗（Adv.）","authors":"Fei Kang, Meng Niu, Zijian Zhou, Mingru Zhang, Hehe Xiong, Fantian Zeng, Jing Wang, Xiaoyuan Chen","doi":"10.1002/adhm.202470177","DOIUrl":null,"url":null,"abstract":"<p><b>Nanovesicles</b></p><p>In article 2400908, Fei Kang, Jing Wang, Xiaoyuan Chen, and co-workers develop CV-Au NVs, defined as concurrent PARP inhibitor sensitization based on radiation-responsive nanovesicles. Upon irradiation, the nanovesicles are disintegrated, spatiotemporally releasing the loaded veliparib (PARP inhibitor) and cisplatin. The combined action of veliparib and cisplatin can increase radiation-induced DNA damage and promote apoptosis of tumor cells, enhancing the chemoradiotherapy efficacy of lung cancer.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 28","pages":""},"PeriodicalIF":10.0000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470177","citationCount":"0","resultStr":"{\"title\":\"Spatiotemporal Concurrent PARP Inhibitor Sensitization Based on Radiation-Responsive Nanovesicles for Lung Cancer Chemoradiotherapy (Adv. Healthcare Mater. 28/2024)\",\"authors\":\"Fei Kang, Meng Niu, Zijian Zhou, Mingru Zhang, Hehe Xiong, Fantian Zeng, Jing Wang, Xiaoyuan Chen\",\"doi\":\"10.1002/adhm.202470177\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Nanovesicles</b></p><p>In article 2400908, Fei Kang, Jing Wang, Xiaoyuan Chen, and co-workers develop CV-Au NVs, defined as concurrent PARP inhibitor sensitization based on radiation-responsive nanovesicles. Upon irradiation, the nanovesicles are disintegrated, spatiotemporally releasing the loaded veliparib (PARP inhibitor) and cisplatin. The combined action of veliparib and cisplatin can increase radiation-induced DNA damage and promote apoptosis of tumor cells, enhancing the chemoradiotherapy efficacy of lung cancer.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":113,\"journal\":{\"name\":\"Advanced Healthcare Materials\",\"volume\":\"13 28\",\"pages\":\"\"},\"PeriodicalIF\":10.0000,\"publicationDate\":\"2024-11-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470177\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Healthcare Materials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202470177\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Healthcare Materials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202470177","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

摘要

纳米微粒在第 2400908 号文章中，Fei Kang、Jing Wang、Xiaoyuan Chen 及合作者开发了 CV-Au NVs，定义为基于辐射响应纳米微粒的 PARP 抑制剂同时增敏。辐照时，纳米颗粒崩解，在时空上释放出负载的veliparib（PARP抑制剂）和顺铂。veliparib和顺铂的联合作用可增加辐射诱导的DNA损伤，促进肿瘤细胞凋亡，从而提高肺癌的放化疗疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Spatiotemporal Concurrent PARP Inhibitor Sensitization Based on Radiation-Responsive Nanovesicles for Lung Cancer Chemoradiotherapy (Adv. Healthcare Mater. 28/2024)

查看原文本刊更多论文

Spatiotemporal Concurrent PARP Inhibitor Sensitization Based on Radiation-Responsive Nanovesicles for Lung Cancer Chemoradiotherapy (Adv. Healthcare Mater. 28/2024)

Nanovesicles

In article 2400908, Fei Kang, Jing Wang, Xiaoyuan Chen, and co-workers develop CV-Au NVs, defined as concurrent PARP inhibitor sensitization based on radiation-responsive nanovesicles. Upon irradiation, the nanovesicles are disintegrated, spatiotemporally releasing the loaded veliparib (PARP inhibitor) and cisplatin. The combined action of veliparib and cisplatin can increase radiation-induced DNA damage and promote apoptosis of tumor cells, enhancing the chemoradiotherapy efficacy of lung cancer.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.