在 Cs2CO3 催化下合成 2,3-二氢苯并[b]氧杂卓衍生物的 Rauhut-Currier 型反应

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

The Journal of Organic Chemistry Pub Date : 2024-10-29 DOI:10.1021/acs.joc.4c0154410.1021/acs.joc.4c01544

Roger López, Omar Jamis-Oliva, Susan Lühr, Antonio Galdámez, Sebastián Gallardo-Fuentes* and Marcelo Vilches-Herrera*,

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引用次数: 0

摘要

融合苯并氧杂卓的合成需要使用复杂的底物和方法。在此，我们报告了在 Cs2CO3 催化下获得这些重要化合物的前所未有的 Rauhut-Currier 型反应的实验和理论发现。所开发的方法避免了使用磷基或胺类催化剂和添加剂。该反应可在微波辐照下进行，并具有完全的化学选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cs2CO3-Catalyzed Rauhut–Currier-Type Reaction for the Synthesis of 2,3-Dihydrobenzo[b]oxepin Derivatives

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Cs2CO3-Catalyzed Rauhut–Currier-Type Reaction for the Synthesis of 2,3-Dihydrobenzo[b]oxepin Derivatives

The synthesis of fused benzoxepines relies on the use of complex substrates and methodologies. Herein, we report our experimental and theoretical findings about an unprecedented Rauhut–Currier-type reaction catalyzed by Cs₂CO₃ to access these important compounds. The developed methodology avoids the use of phosphine- or amine-based catalysts and additives. The reaction can be performed under microwave irradiation and proceeds with complete chemoselectivity.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.