从整个生物体角度到单细胞分辨率的心脏再生。

IF 6.4 1区医学 Q1 CELL & TISSUE ENGINEERING

npj Regenerative Medicine Pub Date : 2024-11-15 DOI:10.1038/s41536-024-00378-8

Xiaoxin Chen, Xiaochen Zhong, Guo N Huang

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引用次数: 0

摘要

动物界的心脏再生潜能在本体和系统发育过程中表现出惊人的差异。在此，我们讨论了心脏再生的几个基本问题，并提供了生物体整体心脏再生的整体视角，以及不同心脏细胞群之间细胞间通讯的单细胞视角。我们希望提供有价值的见解，促进我们对器官再生和未来治疗策略的理解。

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Heart regeneration from the whole-organism perspective to single-cell resolution.

Cardiac regenerative potential in the animal kingdom displays striking divergence across ontogeny and phylogeny. Here we discuss several fundamental questions in heart regeneration and provide both a holistic view of heart regeneration in the organism as a whole, as well as a single-cell perspective on intercellular communication among diverse cardiac cell populations. We hope to provide valuable insights that advance our understanding of organ regeneration and future therapeutic strategies.

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来源期刊

npj Regenerative Medicine Engineering-Biomedical Engineering

CiteScore

10.00

自引率

1.40%

发文量

审稿时长

12 weeks

期刊介绍： Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.