[皮肤老化和皮肤疏松--慢性皮肤脆弱综合征]。

Meropi Karakioulaki
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引用次数: 0

摘要

皮肤老化分为内在老化和外在老化,包括色素老化、血管老化、结缔组织老化和脂肪组织老化。衰老是由基因决定的,但也受到紫外线辐射、空气污染和吸烟等环境因素的影响。皮肤老化不仅会影响美观,还会影响功能,因为细胞外基质(尤其是透明质酸)的流失会损害皮肤的机械功能。透明质酸盐能稳定皮肤结构,起到缓冲作用,减少皮肤撕裂的可能性。皮肤营养不良(Dermatoporosis)是索拉特(Saurat)创造的一个术语,描述了皮肤老化的功能层面,表现为从皮肤萎缩到皮肤坏死等严重并发症的不同阶段。在老年患者中,尤其是 70 岁以上的患者中,这种现象越来越多。发病率从女性的 22% 到男性的 38%,在接受慢性类固醇治疗和某些疾病的患者中发病率更高。诊断可通过临床检查和超声波测量皮肤厚度来进行。预防方法包括限制接触有害因素,并使用透明质酸和外用维甲酸等特定治疗方法来改善皮肤健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Skin aging and dermatoporosis-the chronic skin fragility syndrome].

Skin aging is divided into intrinsic and extrinsic aging, encompassing pigmentary, vascular, connective tissue, and fat tissue aspects that contribute to this complex process. Aging is genetically determined but is influenced by environmental factors such as ultraviolet radiation, air pollution, and smoking. Skin aging has not only cosmetic but also functional implications, as the loss of the extracellular matrix, especially hyaluronate, impairs the mechanical functions of the skin. Hyaluronate, which stabilizes skin structures, acts as a cushion and reduces susceptibility to skin tears. Dermatoporosis, a term coined by Saurat, describes the functional dimension of skin aging, manifesting in various stages from skin atrophy to severe complications like skin necrosis. It is increasingly observed in older patients, particularly from age 70 onwards. Prevalence ranges from 22% in women to 38% in men, with higher rates in patients undergoing chronic steroid therapy and certain conditions. Diagnosis is made through clinical examination and skin thickness measurement via ultrasound. Prevention involves limiting exposure to harmful factors and using specific treatments such as hyaluronic acid and topical retinoids to improve skin health.

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