{"title":"多囊卵巢综合征住院青少年的精神并发症：利用全国住院病人样本进行的横断面研究。","authors":"Chintan Trivedi, Abid Rizvi, Sahar Ashraf, Karrar Husain, Garima Yadav, Erin Adams, Malathi Perugula, Sharmin Nabi, Zeeshan Mansuri, Shailesh Jain","doi":"10.4088/PCC.24m03760","DOIUrl":null,"url":null,"abstract":"<p><p><b>Objective:</b> Polycystic ovary syndrome (PCOS) symptoms extend beyond reproductive issues, impacting mental health significantly, with noted correlations to anxiety, depression, and suicide attempts. The objective of this study was to quantify psychiatric comorbidities among adolescent females with PCOS.</p><p><p><b>Methods:</b> Utilizing the National Inpatient Sample dataset from January 2016 to December 2018, this study examined a cohort of female adolescents aged 14-17 years diagnosed with PCOS, identified via <i>International Classification of Diseases, Tenth Revision, Clinical Modification</i> code E28.2, and matched 1:2 with non-PCOS individuals on demographic variables using propensity score matching. The primary outcomes included the prevalence of psychiatric disorders and were analyzed through categorical and continuous variable comparisons, employing <i>t</i> tests and Rao-Scott adjusted χ<sup>2</sup> tests, with odds ratios calculated to assess associations.</p><p><p><b>Results:</b> The study encompassed 11,985 patients, highlighting a significantly higher prevalence of mood disorders, major depressive disorder, and anxiety disorders in the PCOS cohort compared to controls (<i>P</i> < .001). Specifically, mood disorders were reported in 43.6% of the PCOS group. Attention-deficit/hyperactivity disorder/conduct disorders were also more prevalent in the PCOS population. However, rates of schizophrenia and suicidal ideation/attempts did not significantly differ between groups.</p><p><p><b>Conclusion:</b> Adolescents with PCOS exhibit increased psychiatric comorbidities, highlighting the urgent need for integrated care strategies. Future research should aim to elucidate the mechanisms underlying these associations and develop effective interventions to improve outcomes in this vulnerable population.</p><p><p><i>Prim Care Companion CNS Disord 2024;26(6):24m03760</i>.</p><p><p>\n <i>Author affiliations are listed at the end of this article.</i>\n </p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"26 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Psychiatric Comorbidities in Hospitalized Adolescents With Polycystic Ovary Syndrome: A Cross-Sectional Study Using the National Inpatient Sample.\",\"authors\":\"Chintan Trivedi, Abid Rizvi, Sahar Ashraf, Karrar Husain, Garima Yadav, Erin Adams, Malathi Perugula, Sharmin Nabi, Zeeshan Mansuri, Shailesh Jain\",\"doi\":\"10.4088/PCC.24m03760\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Objective:</b> Polycystic ovary syndrome (PCOS) symptoms extend beyond reproductive issues, impacting mental health significantly, with noted correlations to anxiety, depression, and suicide attempts. The objective of this study was to quantify psychiatric comorbidities among adolescent females with PCOS.</p><p><p><b>Methods:</b> Utilizing the National Inpatient Sample dataset from January 2016 to December 2018, this study examined a cohort of female adolescents aged 14-17 years diagnosed with PCOS, identified via <i>International Classification of Diseases, Tenth Revision, Clinical Modification</i> code E28.2, and matched 1:2 with non-PCOS individuals on demographic variables using propensity score matching. The primary outcomes included the prevalence of psychiatric disorders and were analyzed through categorical and continuous variable comparisons, employing <i>t</i> tests and Rao-Scott adjusted χ<sup>2</sup> tests, with odds ratios calculated to assess associations.</p><p><p><b>Results:</b> The study encompassed 11,985 patients, highlighting a significantly higher prevalence of mood disorders, major depressive disorder, and anxiety disorders in the PCOS cohort compared to controls (<i>P</i> < .001). Specifically, mood disorders were reported in 43.6% of the PCOS group. Attention-deficit/hyperactivity disorder/conduct disorders were also more prevalent in the PCOS population. However, rates of schizophrenia and suicidal ideation/attempts did not significantly differ between groups.</p><p><p><b>Conclusion:</b> Adolescents with PCOS exhibit increased psychiatric comorbidities, highlighting the urgent need for integrated care strategies. Future research should aim to elucidate the mechanisms underlying these associations and develop effective interventions to improve outcomes in this vulnerable population.</p><p><p><i>Prim Care Companion CNS Disord 2024;26(6):24m03760</i>.</p><p><p>\\n <i>Author affiliations are listed at the end of this article.</i>\\n </p>\",\"PeriodicalId\":22814,\"journal\":{\"name\":\"The primary care companion for CNS disorders\",\"volume\":\"26 6\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The primary care companion for CNS disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4088/PCC.24m03760\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The primary care companion for CNS disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4088/PCC.24m03760","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Psychiatric Comorbidities in Hospitalized Adolescents With Polycystic Ovary Syndrome: A Cross-Sectional Study Using the National Inpatient Sample.
Objective: Polycystic ovary syndrome (PCOS) symptoms extend beyond reproductive issues, impacting mental health significantly, with noted correlations to anxiety, depression, and suicide attempts. The objective of this study was to quantify psychiatric comorbidities among adolescent females with PCOS.
Methods: Utilizing the National Inpatient Sample dataset from January 2016 to December 2018, this study examined a cohort of female adolescents aged 14-17 years diagnosed with PCOS, identified via International Classification of Diseases, Tenth Revision, Clinical Modification code E28.2, and matched 1:2 with non-PCOS individuals on demographic variables using propensity score matching. The primary outcomes included the prevalence of psychiatric disorders and were analyzed through categorical and continuous variable comparisons, employing t tests and Rao-Scott adjusted χ2 tests, with odds ratios calculated to assess associations.
Results: The study encompassed 11,985 patients, highlighting a significantly higher prevalence of mood disorders, major depressive disorder, and anxiety disorders in the PCOS cohort compared to controls (P < .001). Specifically, mood disorders were reported in 43.6% of the PCOS group. Attention-deficit/hyperactivity disorder/conduct disorders were also more prevalent in the PCOS population. However, rates of schizophrenia and suicidal ideation/attempts did not significantly differ between groups.
Conclusion: Adolescents with PCOS exhibit increased psychiatric comorbidities, highlighting the urgent need for integrated care strategies. Future research should aim to elucidate the mechanisms underlying these associations and develop effective interventions to improve outcomes in this vulnerable population.
Prim Care Companion CNS Disord 2024;26(6):24m03760.
Author affiliations are listed at the end of this article.
期刊介绍：
Founded in 1998, The Primary Care Companion for CNS Disorders (ISSN 2155-7780), formerly The Primary Care Companion to The Journal of Clinical Psychiatry, is an international, peer-reviewed, online-only journal, and its articles are indexed by the National Library of Medicine. PCC seeks to advance the clinical expertise of primary care physicians and other health care professionals who treat patients with mental and neurologic illnesses. PCC publishes research from disciplines such as medicine, nursing, pharmacy, and psychology, especially as it pertains to integrated delivery systems and interdisciplinary collaboration. PCC focuses on providing information of direct clinical utility and giving a voice to clinician researchers. Practice-based research from individuals and groups with clinical expertise is particularly welcome. Pertinent manuscript types include: -Original research -Systematic reviews -Meta-analyses -Case reports and series -Commenting letters to the editor Articles published in PCC typically cover attention-deficit/hyperactivity disorder, depression, bipolar disorder, anxiety, addiction, sleep disorders, pain, Alzheimer’s disease, multiple sclerosis, and Parkinson’s disease.
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